Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.4.16 extracted from

  • Ionova, I.A.; Vasquez-Vivar, J.; Cooley, B.C.; Khanna, A.K.; Whitsett, J.; Herrnreiter, A.; Migrino, R.Q.; Ge, Z.D.; Regner, K.R.; Channon, K.M.; Alp, N.J.; Pieper, G.M.
    Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection (2010), Am. J. Physiol. Heart Circ. Physiol., 299, H88-H96.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.16

Cloned(Commentary)

Cloned (Comment) Organism
expression of GTPCH under the control of a 935-bp fragment of the mouse myosin heavy chain gene promoter Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information wild-type and transgenic human GTPCH-overexpressing murine donor hearts are transplanted into BALB/c recipient mice via pronuclear injection of oocytes. Cardiac myocyte GTPCH overexpression inhibits cardiac graft rejection, phenotype, overview Mus musculus
additional information wild-type and transgenic human GTPCH-overexpressing murine donor hearts are transplanted into BALB/c recipient mice via pronuclear injection of oocytes. Cardiac myocyte GTPCH overexpression inhibits cardiac graft rejection, phenotype, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Mus musculus C57BL6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiac myocyte
-
 Mus musculus
-
cardiac myocyte
-
 Homo sapiens
-
heart
-
 Mus musculus
-
heart
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
GTPCH
-
 Mus musculus
GTPCH
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction decreases in GTPCH activity and expression in late stages of acute cardiac rejection due to a deficit in BH4 Mus musculus
malfunction decreases in GTPCH activity and expression in late stages of acute cardiac rejection due to a deficit in BH4. Mechanism of the decreased rejection appears related to decreased T cell proliferation and modulation of immune function by higher expression of genes involved in hematopoietic/stromal cell development and recruitment Homo sapiens
metabolism GTP cyclohydrolase I is the rate-limiting enzyme for tetrahydrobiopterin synthesis Mus musculus
metabolism GTP cyclohydrolase I is the rate-limiting enzyme for tetrahydrobiopterin synthesis Homo sapiens
additional information adult cardiac myocytes despite expression of GTPCH mRNA and protein have a defective basal and cytokine-stimulated synthesis of BH4 via the de novo synthesis pathway and impaired synthesis via the salvage pathway in contrast with that typically seen in neonatal cardiac myocytes Homo sapiens
physiological function GTP cyclohydrolase I is the rate-limiting enzyme for tetrahydrobiopterin synthesis. Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection Mus musculus
physiological function GTP cyclohydrolase I is the rate-limiting enzyme for tetrahydrobiopterin synthesis. Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection Homo sapiens