Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.4.16 extracted from

  • Fujiwara, K.; Mori, K.; Kaneko, Y.S.; Nakashima, A.; Nagasaka, A.; Itoh, M.; Ota, A.
    Tetrahydrobiopterin biosynthesis in white and brown adipose tissues is enhanced following intraperitoneal administration of bacterial lipopolysaccharide (2004), Biochim. Biophys. Acta, 1670, 181-198.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
lipolysaccharide commercially isolated from Escherichia coli serotype 026:B6, activates and upregulates the enzyme in adipose tissue, but in cultured 3T3-L1 adipocytes lipolysaccharide addition only increases the enzyme expression level in presence of TNFalpha and interferon gamma, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Mus musculus the enzyme is rate limiting in the tetrahydrobiopterin biosynthesis in adipose tissue, overview formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q05915 precursor; C3H/HeN and C3H/HeJ mice
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell adipocyte cell line Mus musculus
-
brown adipose tissue
-
Mus musculus
-
additional information GCH expression patterns Mus musculus
-
white adipose tissue
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
tissue dependent enzyme activity and effects of cytokines Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
Mus musculus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
?
GTP + H2O the enzyme is rate limiting in the tetrahydrobiopterin biosynthesis in adipose tissue, overview Mus musculus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
?

Synonyms

Synonyms Comment Organism
GCH
-
Mus musculus
GCH1
-
Mus musculus