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Literature summary for 3.5.4.16 extracted from

  • Blau, N.; Niederwieser, A.
    GTP-cyclohydrolases: mini-review (1984), Biochem. Clin. Aspects Pteridines, 3, 77-92.
No PubMed abstract available
Search for more literature for 3.5.4.16

Inhibitors

Inhibitors Comment Organism Structure
ADP competitive inhibitor Escherichia coli
ATP
-
 Drosophila melanogaster
ATP competitive inhibitor Escherichia coli
ATP
-
 Serratia indica
Ca2+
-
 Drosophila melanogaster
Ca2+
-
 Geobacillus stearothermophilus
Cu2+
-
 Escherichia coli
Cu2+
-
 Gallus gallus
Cu2+
-
 Geobacillus stearothermophilus
Cu2+
-
 Rattus norvegicus
Cu2+
-
 Serratia indica
dGTP
-
 Drosophila melanogaster
dGTP competitive inhibitor Escherichia coli
GDP
-
 Drosophila melanogaster
GDP
-
 Serratia indica
guanosine 5'-tetraphosphate
-
 Escherichia coli
Hg2+
-
 Escherichia coli
Hg2+
-
 Gallus gallus
Hg2+
-
 Geobacillus stearothermophilus
Hg2+
-
 Serratia indica
Mg2+
-
 Drosophila melanogaster
Mg2+
-
 Lactiplantibacillus plantarum
Mg2+
-
 Rattus norvegicus
PO43- uncompetitive inhibitor Escherichia coli
TTP competitive inhibitor Escherichia coli
UTP competitive inhibitor Escherichia coli
Zn2+
-
 Drosophila melanogaster
Zn2+
-
 Serratia indica

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Lactiplantibacillus plantarum
additional information
-
 additional information
-
 Escherichia coli
additional information
-
 additional information
-
 Rattus norvegicus
additional information
-
 additional information
-
 Geobacillus stearothermophilus
additional information
-
 additional information
-
 Serratia indica
additional information
-
 additional information
-
 Comamonas sp.

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Escherichia coli
Mg2+ activates Rattus norvegicus
Mg2+ activates Comamonas sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Lactiplantibacillus plantarum first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
GTP + H2O Escherichia coli first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
GTP + H2O Rattus norvegicus first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
GTP + H2O Geobacillus stearothermophilus first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
GTP + H2O Serratia indica first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
GTP + H2O Comamonas sp. first step in pathway of pterins formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Comamonas sp.
-
-
-
Drosophila melanogaster
-
-
-
Escherichia coli
-
-
-
Gallus gallus
-
-
-
Geobacillus stearothermophilus
-
-
-
Lactiplantibacillus plantarum
-
 alpha1, alpha and beta
-
Rattus norvegicus
-
-
-
Serratia indica
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Gallus gallus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Gallus gallus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
GTP + H2O
-
 Drosophila melanogaster formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
GTP + H2O
-
 Lactiplantibacillus plantarum formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
GTP + H2O
-
 Escherichia coli formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
GTP + H2O
-
 Rattus norvegicus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
GTP + H2O
-
 Geobacillus stearothermophilus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
GTP + H2O
-
 Serratia indica formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
GTP + H2O
-
 Comamonas sp. formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
GTP + H2O first step in pathway of pterins Lactiplantibacillus plantarum formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
GTP + H2O first step in pathway of pterins Escherichia coli formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
GTP + H2O first step in pathway of pterins Rattus norvegicus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
GTP + H2O first step in pathway of pterins Geobacillus stearothermophilus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
GTP + H2O first step in pathway of pterins Serratia indica formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?
GTP + H2O first step in pathway of pterins Comamonas sp. formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
-
 Lactiplantibacillus plantarum
additional information
-
-
 Escherichia coli
additional information
-
-
 Rattus norvegicus
additional information
-
-
 Geobacillus stearothermophilus
additional information
-
-
 Serratia indica
additional information
-
-
 Comamonas sp.