Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dTTP | the inhibitor has a regukatory function for the bifunctional enzyme, mechanism of regulation by conformational changes, overview | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | steady-state kinetic analysis | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dCTP + H2O | Mycobacterium tuberculosis | - |
dUTP + NH3 | - |
? | |
dCTP + H2O | Mycobacterium tuberculosis H37Rv | - |
dUTP + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WP17 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WP17 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
dCTP + H2O = dUTP + NH3 | the mechanism for the deamination of dCTP involves the four residues Ser102, Arg106, Ala115 and Glu129, structure-function relationship of the bifunctional enzyme, overview | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dCTP + H2O | - |
Mycobacterium tuberculosis | dUTP + NH3 | - |
? | |
dCTP + H2O | - |
Mycobacterium tuberculosis H37Rv | dUTP + NH3 | - |
? | |
additional information | the enzyme is a bifunctional dCTP deaminase:dUTPase | Mycobacterium tuberculosis | ? | - |
? | |
additional information | the enzyme is a bifunctional dCTP deaminase:dUTPase | Mycobacterium tuberculosis H37Rv | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dCTP deaminase:deoxyuridine triphosphatase | - |
Mycobacterium tuberculosis |
dCTP deaminase:dUTPase | - |
Mycobacterium tuberculosis |
deoxycytidine triphosphate deaminase | - |
Mycobacterium tuberculosis |