Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dCMP | allosterically increases dCMPD activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dGMP | potent competitive inhibitor | Homo sapiens | |
dTTP | inhibits dCMPD by allosteric interaction | Homo sapiens | |
dUMP | potent competitive inhibitor | Homo sapiens | |
GMP | potent competitive inhibitor | Homo sapiens | |
additional information | monophosphates of deoxycytidine analogs nucleosides in the L-conformation (e.g. apricitabine, lamivudine, and emtricitabine) and dideoxycytidine do not act as inhibitors of dCMPD | Homo sapiens | |
tetrahydrodeoxyuridine | - |
Homo sapiens | |
TTP | inhibits dCMPD by allosteric interaction | Homo sapiens | |
zebularine | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dCMP + H2O | Homo sapiens | - |
dUMP + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(+)-FTCMP + H2O | - |
Homo sapiens | ? | - |
? | |
2',3'-dideoxy-5-fluoro-3'-thiacytidine + H2O | good substrate | Homo sapiens | ? | - |
? | |
5-aza-dCMP + H2O | - |
Homo sapiens | 5-aza-dUMP + NH3 | - |
? | |
ara-CMP + H2O | fair substrate | Homo sapiens | ara-UMP + NH3 | - |
? | |
dCMP + H2O | - |
Homo sapiens | dUMP + NH3 | - |
? | |
additional information | cytidine monophosphate is not a good substrate for dCMPD. Monophosphates of deoxycytidine analogs nucleosides in the L-conformation (e.g. apricitabine, lamivudine, and emtricitabine) and dideoxycytidine do not act as substrates of dCMPD | Homo sapiens | ? | - |
? | |
PSI-6130-MP + H2O | weak substrate | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dCMPD | - |
Homo sapiens |
deoxycytidine monophosphate deaminase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | dCMPD is pivotal in deoxyuridine analogs nucleotide formation | Homo sapiens |