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Literature summary for 3.5.4.11 extracted from
- Catabolism of pteridine cofactors. II. A specific pterin deaminase in rat liver (1969), Biochim. Biophys. Acta, 184, 589-596.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 4-chloromercuribenzoate | 0.1-1 mM, about 25% increase in activity | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Azaguanine | 0.00145 mM, 57% inhibition | Rattus norvegicus | |
| CN- | 0.5 mM, 48% inhibition | Rattus norvegicus | |
| lumazine | 0.00145 mM, 57% inhibition | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
2-Amino-4-hydroxypteridine | pH 6.5, 37°C | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Apis mellifera | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| larva | highest activity in 4-day-old larva | Apis mellifera | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-amino-4-hydroxypteridine + H2O | i.e. pterin. The enzyme specifically deaminates pterin, isoxanthopterin and tetrahydropterin | Rattus norvegicus | 2,4-dihydroxypteridine + NH3 | i.e. lumazine | ? | |
| 2-amino-5,6,7,8-tetrahydropteridin-4(1H)-one + H2O | the enzyme specifically deaminates pterin, isoxanthopterin and tetrahydropterin | Rattus norvegicus | 5,6,7,8-tetrahydropteridine-2,4(1H,3H)-dione + NH3 | - |
? | |
| 2-aminopteridine-4,7(1H,8H)-dione + H2O | i.e. isoxanthopterin. The enzyme specifically deaminates pterin, isoxanthopterin and tetrahydropterin | Rattus norvegicus | 7-hydroxypteridine-2,4(1H,3H)-dione + NH3 | i.e. 7-hydroxylumazine | ? | |
| additional information | xanthopterin, biopterin, neopterin, pterin-6-carboxylic acid, and 6-hydroxymethylpterin are not deaminated | Rattus norvegicus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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