Protein Variants | Comment | Organism |
---|---|---|
D125A | 10fold increase in KM-value | Homo sapiens |
D125E | 5fold increase in Km-value | Homo sapiens |
D125N | 3fold increase in Km-value | Homo sapiens |
K137A | 30fold increase in KM-value, 30fold decrease in kcat-value | Homo sapiens |
K137R | 3fold increase in KM-value15fold decrease in kcat-value | Homo sapiens |
K66A | more than 100fold increase in KM-value | Homo sapiens |
Y104A | decrease in kcat-value by one orders of magnitude | Homo sapiens |
Y104A/D125A | no enzymic activity | Homo sapiens |
Y104F | decrease in kcat-value by two orders of magnitude | Homo sapiens |
Y104F/D125A | no enzymice activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0009 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, wild-type | Homo sapiens | |
0.0027 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutant D125N | Homo sapiens | |
0.0027 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutant K137R | Homo sapiens | |
0.003 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutant Y104A | Homo sapiens | |
0.0036 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutant Y104F | Homo sapiens | |
0.0052 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutant D125E | Homo sapiens | |
0.0091 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutant D125A | Homo sapiens | |
0.031 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutant K137A | Homo sapiens | |
0.115 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutant K66A | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
bifunctional aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | - |
Homo sapiens | IMP + H2O | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.014 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutantD125A | Homo sapiens | |
0.036 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutantY104F | Homo sapiens | |
0.062 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutantK66A | Homo sapiens | |
0.136 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutantY104A | Homo sapiens | |
0.147 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutant D125E | Homo sapiens | |
0.276 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutantK137A | Homo sapiens | |
0.507 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutant K137R | Homo sapiens | |
0.603 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, mutant D125N | Homo sapiens | |
8.6 | - |
5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | pH 7.5, 22°C, wild-type | Homo sapiens |