Literature summary for 3.5.4.10 extracted from

Christopherson, R.I.; Williams, N.K.; Schoettle, S.L.; Szabados, E.; Hambley, T.W.; Manthey, M.K.
Inhibitors of dihydroorotase, amidophosphoribosyltransferase and IMP cyclohydrolase as potential drugs (1995), Biochem. Soc. Trans., 23, 888-893.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-fluoroadenine arabinoside 5'-monophosphate	strong competitive inhibitor, derivative of anti-cancer drug	Homo sapiens
2-mercaptoinosine 5'-monophosphate	most potent competitive inhibitor, precursor of GMP in the purine pathway	Homo sapiens
6-mercaptopurine riboside 5'-monophosphate	strong competitive inhibitor, derivative of anti-cancer drug	Homo sapiens
adenosine N1-oxide 5'-monophosphate	strong competitive inhibitor	Homo sapiens
N6-(carboxymethyl)adenosine 5'-monophosphate	strong competitive inhibitor	Homo sapiens
xanthosine 5'-monophosphate	strong competitive inhibitor	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide	Homo sapiens	de novo purine synthesis step 10	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
CEM cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide	de novo purine synthesis step 10	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)