Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-deoxy-AMP | decreased IMP cyclohydrolase activity by 10-50% | Homo sapiens | |
2-fluoroadenine arabinoside 5'-monophosphate | IC50-value in cell culture 0.0002 mM; strong competitive inhibitor, derivative of anti-cancer drug | Homo sapiens | |
2-mercaptoinosine 5'-monophosphate | most potent competitive inhibitor, precursor of GMP in the purine pathway | Homo sapiens | |
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside | decreased IMP cyclohydrolase activity by 10-50% | Homo sapiens | |
6-mercaptopurine riboside 5'-monophosphate | IC50-value in cell culture 0.0075 mM; strong competitive inhibitor, derivative of anti-cancer drug | Homo sapiens | |
adenosine N1-oxide 5'-monophosphate | IC50-value in cell culture 0.0011 microM; strong competitive inhibitor | Homo sapiens | |
AMP | decreased IMP cyclohydrolase activity by 10-50% | Homo sapiens | |
GMP | decreased IMP cyclohydrolase activity by 10-50% | Homo sapiens | |
IMP | decreased IMP cyclohydrolase activity by 10-50% | Homo sapiens | |
N-succino-AMP | decreased IMP cyclohydrolase activity by 10-50% | Homo sapiens | |
N2-acetyl-2'deoxyguanosine 5'-monophosphate | decreased IMP cyclohydrolase activity by 10-50% | Homo sapiens | |
N6-(carboxymethyl)adenosine 5'-monophosphate | strong competitive inhibitor | Homo sapiens | |
xanthosine 5'-monophosphate | strong competitive inhibitor | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
62100 | - |
2 * 62100, protein mobility assay | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | Homo sapiens | de novo purine synthesis step 10 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
780fold to apparent homogeneity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CEM cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide | de novo purine synthesis step 10 | Homo sapiens | ? | - |
? | |
5-formamidoimidazole-4-carboxamide | - |
Homo sapiens | hypoxanthine + H2O | - |
ir |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 62100, protein mobility assay | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
- |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000011 | - |
IC50-value in cell culture 0.0011 microM | Homo sapiens | adenosine N1-oxide 5'-monophosphate | |
0.0002 | - |
IC50-value in cell culture 0.0002 mM | Homo sapiens | 2-fluoroadenine arabinoside 5'-monophosphate | |
0.0075 | - |
IC50-value in cell culture 0.0075 mM | Homo sapiens | 6-mercaptopurine riboside 5'-monophosphate |