Literature summary for 3.5.4.1 extracted from

McManus, B.A.; Moran, G.P.; Higgins, J.A.; Sullivan, D.J.; Coleman, D.C.
A Ser29Leu substitution in the cytosine deaminase Fca1p is responsible for clade-specific flucytosine resistance in Candida dubliniensis (2009), Antimicrob. Agents Chemother., 53, 4678-4685.

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Protein Variants

Protein Variants	Comment	Organism
S29L	the substitution in the cytosine deaminase Fca1p is responsible for clade-specific fluorocytosine resistance in Candida dubliniensis	Candida dubliniensis

Organism

Organism	UniProt	Comment	Textmining
Candida dubliniensis	-	-	-
Candida dubliniensis isolates SA113, SA109, Eg202, Eg204 and p7276	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-fluorocytosine + H2O	-	Candida dubliniensis	5-fluorouracil + NH3	-	?
5-fluorocytosine + H2O	-	Candida dubliniensis isolates SA113, SA109, Eg202, Eg204 and p7276	5-fluorouracil + NH3	-	?

Synonyms

Synonyms	Comment	Organism
Fca1p	-	Candida dubliniensis

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Release 2023.1 (January 2023)