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Literature summary for 3.5.4.1 extracted from

  • Yao, L.; Yan, H.; Cukier, R.I.
    A combined ONIOM quantum chemical-molecular dynamics study of zinc-uracil bond breaking in yeast cytosine deaminase (2006), J. Phys. Chem. B, 110, 26320-26326.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine + H2O Saccharomyces cerevisiae
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uracil + NH3
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?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorocytosine + H2O activation of the prodrug, product release is the rate-limiting step during the activation to the anticancer drug 5-fluorouracil Saccharomyces cerevisiae 5-fluorouracil + NH3
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?
cytosine + H2O
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Saccharomyces cerevisiae uracil + NH3
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?
cytosine + H2O the cytosine deamination proceeds via a sequential mechanism involving the protonation of the N3 of cytosine, a nucleophilic attack on C4 by the Zn-coordinated hydroxide, and the cleavage of the C4-N4 bond, combined two-layer ONIOM quantum chemical-molecular dynamics study, method, development, overview Saccharomyces cerevisiae uracil + NH3
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?