Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine + H2O | Saccharomyces cerevisiae | - |
uracil + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorocytosine + H2O | activation of the prodrug, product release is the rate-limiting step during the activation to the anticancer drug 5-fluorouracil | Saccharomyces cerevisiae | 5-fluorouracil + NH3 | - |
? | |
cytosine + H2O | - |
Saccharomyces cerevisiae | uracil + NH3 | - |
? | |
cytosine + H2O | the cytosine deamination proceeds via a sequential mechanism involving the protonation of the N3 of cytosine, a nucleophilic attack on C4 by the Zn-coordinated hydroxide, and the cleavage of the C4-N4 bond, combined two-layer ONIOM quantum chemical-molecular dynamics study, method, development, overview | Saccharomyces cerevisiae | uracil + NH3 | - |
? |