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Literature summary for 3.5.3.6 extracted from
- Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase (2012), Br. J. Cancer, 106, 324-332.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| arginine deiminase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | argininosuccinate synthetase-deficient SCLC cells demonstrate sensitivity to pegylated ADI (ADI-PEG20), which is associated with the induction of autophagy and caspasein-dependent cell death. Arginine deiminase-PEG20 treatment of ASS-negative SCLC xenografts causes significant, dose-dependent inhibition of tumour growth of both small and established tumours | Homo sapiens |
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Release 2023.1 (January 2023)
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