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BRENDA support

Literature summary for 3.5.3.6 extracted from

  • Glazer, E.S.; Piccirillo, M.; Albino, V.; Di Giacomo, R.; Palaia, R.; Mastro, A.A.; Beneduce, G.; Castello, G.; De Rosa, V.; Petrillo, A.; Ascierto, P.A.; Curley, S.A.; Izzo, F.
    Phase II study of pegylated arginine deiminase for nonresectable and metastatic hepatocellular carcinoma (2010), J. Clin. Oncol., 28, 2220-2226.
    View publication on PubMed

Application

Application Comment Organism
medicine pegylated ADI is a promising drug that capitalizes on a significant enzymatic deficiency in human hepatocellular carcinoma Mycoplasma sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + H2O Mycoplasma sp.
-
L-citrulline + NH3
-
?

Organism

Organism UniProt Comment Textmining
Mycoplasma sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O
-
Mycoplasma sp. L-citrulline + NH3
-
?

Synonyms

Synonyms Comment Organism
ADI
-
Mycoplasma sp.