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Literature summary for 3.5.3.6 extracted from

  • Bowles, T.L.; Kim, R.; Galante, J.; Parsons, C.M.; Virudachalam, S.; Kung, H.J.; Bold, R.J.
    Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase (2008), Int. J. Cancer, 123, 1950-1955.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.3.6

Application

Application Comment Organism
medicine arginine deprivation by arginine deiminase I can provide a beneficial strategy for the treatment of pancreatic cancer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens arginine deiminase formulated with polyethyleneglycol specifically inhibits growth of cell lines lacking argininosuccinate synthetase, inducing caspase activation and induction of apoptosis ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
L3.3 cell
-
 Homo sapiens
-
MiaPaCa-2 cell
-
 Homo sapiens
-
PANC-1 cell
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
pancreatic cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Arg + H2O
-
 Homo sapiens citrulline + NH3
-
 ?
additional information arginine deiminase formulated with polyethyleneglycol specifically inhibits growth of cell lines lacking argininosuccinate synthetase, inducing caspase activation and induction of apoptosis Homo sapiens ?
-
 ?