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Literature summary for 3.5.2.3 extracted from

  • Washabaugh, M.W.; Collins, K.D.
    Dihydroorotase from Escherichia coli. Purification and characterization (1984), J. Biol. Chem., 259, 3293-3298.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.076
-
dihydro-DL-orotate
-
Escherichia coli
1.07
-
N-carbamoyl-DL-aspartate
-
Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ 0.95 tightly bound zinc atoms per subunit Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38300
-
2 * 38300, SDS-PAGE Escherichia coli
80900
-
ultracentrifugation Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-carbamoyl-L-aspartate Escherichia coli
-
L-dihydroorotate + H2O
-
r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
278
-
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydro-DL-orotate + H2O
-
Escherichia coli N-carbamoyl-L-aspartate
-
r
L-carbamoylaspartate
-
Escherichia coli L-dihydroorotate + H2O
-
r
N-carbamoyl-DL-aspartate
-
Escherichia coli dihydroorotate + H2O
-
r
N-carbamoyl-L-aspartate
-
Escherichia coli L-dihydroorotate + H2O
-
r

Subunits

Subunits Comment Organism
dimer 2 * 38300, SDS-PAGE Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
127
-
dihydro-DL-orotate
-
Escherichia coli
195
-
N-carbamoyl-DL-aspartate
-
Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.8
-
cyclisation of L-carbamoylaspartate Escherichia coli
8
-
hydrolysis of L-dihydroorotate Escherichia coli