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Literature summary for 3.5.2.2 extracted from
- Acid-base catalytic mechanism of dihydropyrimidinase from pH studies (1993), Biochemistry, 32, 5160-5166.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,6-dipicolinic acid | - |
Bos taurus |  |
| 2,6-dipicolinic acid | - |
Sus scrofa | |
| 4-ureidobutyric acid | - |
Sus scrofa | |
| 5-amino-n-valeric acid | - |
Sus scrofa | |
| 8-Hydroxyquinoline-5-sulfonic acid | - |
Bos taurus | |
| 8-Hydroxyquinoline-5-sulfonic acid | - |
Sus scrofa | |
| beta-Alanine | - |
Sus scrofa | |
| glutaric acid monoamide | - |
Sus scrofa | |
| N-Carbamoyl-beta-alanine | - |
Sus scrofa | |
| propionic acid | - |
Sus scrofa | |
| propionic acid amide | - |
Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 54000 | - |
4 * 54000, SDS-PAGE | Sus scrofa |
| 210000 | - |
- |
Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,6-dihydrouracil + H2O | Sus scrofa | - |
3-ureidopropionate | - |
r | |
| 5,6-dihydrouracil + H2O | Bos taurus | - |
3-ureidopropionate | - |
r | |
| hydantoin + H2O | Sus scrofa | - |
N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | Bos taurus | - |
N-carbamoyl glycine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf | - |
| Sus scrofa | - |
pig | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Sus scrofa | - |
| liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.06 | - |
- |
Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,6-dihydrouracil + H2O | - |
Sus scrofa | 3-ureidopropionate | - |
r | |
| 5,6-dihydrouracil + H2O | - |
Bos taurus | 3-ureidopropionate | - |
r | |
| 5-bromo-5,6-dihydrouracil + H2O | - |
Sus scrofa | ? | - |
r | |
| 5-bromo-5,6-dihydrouracil + H2O | - |
Bos taurus | ? | - |
r | |
| glutarimide + H2O | - |
Sus scrofa | ? | - |
? | |
| glutarimide + H2O | - |
Bos taurus | ? | - |
? | |
| hydantoin + H2O | - |
Sus scrofa | N-carbamoyl glycine | - |
? | |
| hydantoin + H2O | - |
Bos taurus | N-carbamoyl glycine | - |
? | |
| N-carbamoyl beta-alanine + H2O | - |
Sus scrofa | 5,6-dihydrouracil | - |
r | |
| N-carbamoyl beta-alanine + H2O | - |
Bos taurus | 5,6-dihydrouracil | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | - |
Bos taurus |
| tetramer | 4 * 54000, SDS-PAGE | Sus scrofa |
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