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Literature summary for 3.5.2.19 extracted from

  • Hamano, Y.; Maruyama, C.; Kimoto, H.
    Construction of a knockout mutant of the Streptothricin-resistance gene in Streptomyces albulus by electroporation (2006), Actinomycetologica, 20, 35-41.
No PubMed abstract available
Search for more literature for 3.5.2.19

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptomyces albulus the true role of SttH may not be its involvement in resistance against streptothricins, instead, it may catalyze the hydrolysis of naturally occurring cyclic amide compounds in the metabolism of Streptomyces albulus ?
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 ?
additional information Streptomyces albulus NBRC14147 the true role of SttH may not be its involvement in resistance against streptothricins, instead, it may catalyze the hydrolysis of naturally occurring cyclic amide compounds in the metabolism of Streptomyces albulus ?
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 ?

Organism

Organism UniProt Comment Textmining
Streptomyces albulus Q1MW86
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Streptomyces albulus NBRC14147 Q1MW86
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the true role of SttH may not be its involvement in resistance against streptothricins, instead, it may catalyze the hydrolysis of naturally occurring cyclic amide compounds in the metabolism of Streptomyces albulus Streptomyces albulus ?
-
 ?
additional information this enzyme catalyzes the hydrolysis of the amide bond of streptolidine lactam, thereby conferring streptothricin resistance Streptomyces albulus ?
-
 ?
additional information the true role of SttH may not be its involvement in resistance against streptothricins, instead, it may catalyze the hydrolysis of naturally occurring cyclic amide compounds in the metabolism of Streptomyces albulus Streptomyces albulus NBRC14147 ?
-
 ?
additional information this enzyme catalyzes the hydrolysis of the amide bond of streptolidine lactam, thereby conferring streptothricin resistance Streptomyces albulus NBRC14147 ?
-
 ?

Synonyms

Synonyms Comment Organism
sttH
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 Streptomyces albulus

General Information

General Information Comment Organism
malfunction construction of an sttH gene-knockout mutant. The minimum inhibitory concentration MIC of Streptothricins in the sttH gene-knockout mutant is determined to be 6.25 mg/ml, whereas the MIC of streptothricins in the Streptomyces albulus wild strain is determined to be above 400 mg/ml. This result clearly demonstrate that sttH is the sole gene responsible for streptothricin resistance in the Streptomyces albulus strain Streptomyces albulus
physiological function sttH gene is not essential for growth. The true role of SttH may not be its involvement in resistance against streptothricins, instead, it may catalyze the hydrolysis of naturally occurring cyclic amide compounds in the metabolism of Streptomyces albulus Streptomyces albulus