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Literature summary for 3.5.1.B13 extracted from

  • Breazeale, S.D.; Ribeiro, A.A.; McClerren, A.L.; Raetz, C.R.
    A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose (2005), J. Biol. Chem., 280, 14154-14167.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-deoxy-4-formamido-beta-L-arabinopyranosyl undecaprenyl phosphate + H2O Escherichia coli because the L-Ara4N unit attached to lipid A is not derivatized with a formyl group, the existence of a deformylase, acting later in the pathway, is postulated. The requirement of the ArnA formyltransferase reaction for the maintenance of polymyxin resistance suggests that an as yet unidentified deformylase must also exist, since neither L-Ara4N-modified lipid A nor the L-Ara4N donor, undecaprenyl phosphate-L-Ara4N, is formylated when isolated from polymyxin resistant cells 4-amino-4-deoxy-alpha-L-arabinose-undecaprenyl phosphate + formate
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Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-deoxy-4-formamido-beta-L-arabinopyranosyl undecaprenyl phosphate + H2O
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Escherichia coli 4-amino-4-deoxy-alpha-L-arabinose-undecaprenyl phosphate + formate
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4-deoxy-4-formamido-beta-L-arabinopyranosyl undecaprenyl phosphate + H2O because the L-Ara4N unit attached to lipid A is not derivatized with a formyl group, the existence of a deformylase, acting later in the pathway, is postulated. The requirement of the ArnA formyltransferase reaction for the maintenance of polymyxin resistance suggests that an as yet unidentified deformylase must also exist, since neither L-Ara4N-modified lipid A nor the L-Ara4N donor, undecaprenyl phosphate-L-Ara4N, is formylated when isolated from polymyxin resistant cells Escherichia coli 4-amino-4-deoxy-alpha-L-arabinose-undecaprenyl phosphate + formate
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Synonyms

Synonyms Comment Organism
polymyxin resistance protein pmrJ
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Escherichia coli
undecaprenyl-phosphate-alpha-L-Ara4FN deformylase
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Escherichia coli