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Literature summary for 3.5.1.98 extracted from

  • Ma, P.; Schultz, R.M.
    Histone deacetylase 2 (HDAC2) regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse (2013), PLoS Genet., 9, e1003377.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.98

Protein Variants

Protein Variants Comment Organism
additional information generation of homozygous Hdac2-/- and heterozygous Hdac1-/+/Hdac2-/- isozyne HDAC2 knockout mutant oocytes, penotypes overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-Lys16-histone H4 + H2O Mus musculus
-
 acetate + histone H4
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P70288 isozyme HDAC2
-

Source Tissue

Source Tissue Comment Organism Textmining
oocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-Lys16-histone H4 + H2O
-
 Mus musculus acetate + histone H4
-
 ?

Synonyms

Synonyms Comment Organism
HDAC2
-
 Mus musculus
histone deacetylase 2
-
 Mus musculus

General Information

General Information Comment Organism
malfunction depleting maternal isozyme HDAC2 results in hyperacetylation of H4K16, while normal deacetylation of other lysine residues of histone H3 or H4 is observed, and defective chromosome condensation and segregation during oocyte maturation occurs in a subpopulation of oocytes, leading to increased incidence of aneuploidy likely accounts for the observed sub-fertility of mice harboring Hdac2-defective oocytes. The infertility of mice harboring Hdac1-/+/Hdac2-/- oocytes is attributed to failure of those few eggs that properly mature to metaphase II to initiate DNA replication following fertilization. Hdac1-/+/Hdac2-/- eggs are fertilized but fail to initiate DNA replication. The increased amount of acetylated H4K16 likely impairs kinetochore function in oocytes lacking isozyme HDAC2 because kinetochores in mutant oocytes are less able to form coldstable microtubule attachments and less CENP-A is located at the centromere. Phenotype, overview Mus musculus
physiological function histone deacetylase 2 regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse. HDAC2 is the major isozyme that regulates global histone acetylation during oocyte development and is largely responsible for the deacetylation of H4K16 during maturation. Histone deacetylation that occurs during oocyte maturation is critical for proper chromosome segregation Mus musculus