Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.1.98 extracted from

  • Hnilicova, J.; Hozeifi, S.; Duskova, E.; Icha, J.; Tomankova, T.; Stanek, D.
    Histone deacetylase activity modulates alternative splicing (2011), PLoS ONE, 6, e16727.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.98

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

General Information

General Information Comment Organism
physiological function activity of histone deacetylases influences splice site selection. Splicing of 700 genes in heLa cells is altered after HDAC inhibition. HDAC inhibition induces histone H4 acetylation and increases RNA Polymerase II processivity along an alternatively spliced element. In addition, HDAC inhibition reduces co-transcriptional association of the splicing regulator SRp40 with the target fibronectin exon. The depletion of HDAC1 has similar effect on fibronectin alternative splicing as global HDAC inhibition. This effect is reversed upon expression of mouse HDAC1 but not a catalytically inactive mutant Homo sapiens