Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)thiophen-2-yl]-2,2,2-trifluoroethanone | - |
Homo sapiens | |
1-[5-(4-acetylphenyl)thiophen-2-yl]-2,2,2-trifluoroethanone | - |
Homo sapiens | |
2,2,2-trifluoro-1-(2-phenyl-1,3-thiazol-5-yl)ethanone | - |
Homo sapiens | |
2,2,2-trifluoro-1-(4-phenylthiophen-2-yl)ethanone | - |
Homo sapiens | |
2,2,2-trifluoro-1-(5-phenylthiophen-2-yl)ethanone | - |
Homo sapiens | |
2,2,2-trifluoro-1-(5-[3-[(methylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone | potent inhibitor of HDAC4 and shows more than 100fold selectivity overHDAC1 | Homo sapiens | |
2,2,2-trifluoro-1-(5-[3-[(propylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone | - |
Homo sapiens | |
2,2,2-trifluoro-1-(5-[3-[(thiophen-2-ylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone | - |
Homo sapiens | |
2,2,2-trifluoro-1-[5-(1H-indol-5-yl)thiophen-2-yl]ethanone | - |
Homo sapiens | |
2,2,2-trifluoro-1-[5-(2-methoxyphenyl)thiophen-2-yl]ethanone | - |
Homo sapiens | |
2,2,2-trifluoro-1-[5-(3-methoxyphenyl)thiophen-2-yl]ethanone | - |
Homo sapiens | |
2,2,2-trifluoro-1-[5-(3-[[(4-fluorobenzyl)sulfonyl]methyl]-1,2,4-oxadiazol-5-yl)thiophen-2-yl]ethanone | - |
Homo sapiens | |
2,2,2-trifluoro-1-[5-(4-methoxyphenyl)thiophen-2-yl]ethanone | - |
Homo sapiens | |
2,2,2-trifluoro-1-[5-(pyridin-2-yl)thiophen-2-yl]ethanone | - |
Homo sapiens | |
2,2,2-trifluoro-1-[5-(quinoxalin-6-yl)thiophen-2-yl]ethanone | - |
Homo sapiens | |
3-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid | the inhibitor shows 40fold selectivity for HDAC4 and 180fold for HDAC6 against HDAC1 | Homo sapiens | |
4-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid | - |
Homo sapiens | |
4-[5-(trifluoroacetyl)thiophen-2-yl]benzonitrile | - |
Homo sapiens | |
additional information | 3-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid shows no inhibition of HDAC1 at 0.01 mM, 2,2,2-trifluoro-1-[5-(pyridin-2-yl)thiophen-2-yl]ethanone is inactive against HDAC6, 2,2,2-trifluoro-1-[5-(1H-indol-5-yl)thiophen-2-yl]ethanone is essentially inactive against HDAC1 and 4 | Homo sapiens | |
N-methyl-N-(quinoxalin-6-ylmethyl)-5-(trifluoroacetyl)thiophene-2-carboxamide | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-lysine-histone H3 + H2O | Homo sapiens | - |
acetate + histone H3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-tubulin + H2O | - |
Homo sapiens | acetate + ? | - |
? | |
N-acetyl-lysine-histone H3 + H2O | - |
Homo sapiens | acetate + histone H3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDAC1 | class I histone deacetylase | Homo sapiens |
HDAC4 | class II histone deacetylase | Homo sapiens |
HDAC6 | class II histone deacetylase | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000015 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(quinoxalin-6-yl)thiophen-2-yl]ethanone | |
0.000024 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(5-[3-[(methylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone | |
0.000027 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | 4-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid | |
0.000029 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | 1-[5-(4-acetylphenyl)thiophen-2-yl]-2,2,2-trifluoroethanone | |
0.00003 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(5-[3-[(propylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone | |
0.000035 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(5-[3-[(thiophen-2-ylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone | |
0.000037 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | 1-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)thiophen-2-yl]-2,2,2-trifluoroethanone | |
0.000041 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | 4-[5-(trifluoroacetyl)thiophen-2-yl]benzonitrile | |
0.00006 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(3-[[(4-fluorobenzyl)sulfonyl]methyl]-1,2,4-oxadiazol-5-yl)thiophen-2-yl]ethanone | |
0.00007 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | 3-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid | |
0.000089 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | N-methyl-N-(quinoxalin-6-ylmethyl)-5-(trifluoroacetyl)thiophene-2-carboxamide | |
0.000098 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | N-methyl-N-(quinoxalin-6-ylmethyl)-5-(trifluoroacetyl)thiophene-2-carboxamide | |
0.00011 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(4-methoxyphenyl)thiophen-2-yl]ethanone | |
0.00013 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(2-phenyl-1,3-thiazol-5-yl)ethanone | |
0.00016 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 4-[5-(trifluoroacetyl)thiophen-2-yl]benzonitrile | |
0.00016 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(quinoxalin-6-yl)thiophen-2-yl]ethanone | |
0.00017 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(5-phenylthiophen-2-yl)ethanone | |
0.00021 | - |
HDAC6 pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(2-phenyl-1,3-thiazol-5-yl)ethanone | |
0.00023 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(5-[3-[(methylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone | |
0.00024 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(5-[3-[(propylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone | |
0.00031 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 3-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid | |
0.00052 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(5-[3-[(thiophen-2-ylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone | |
0.00054 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(pyridin-2-yl)thiophen-2-yl]ethanone | |
0.00058 | - |
HDAC1, pH and temperature not specified in the publication | Homo sapiens | N-methyl-N-(quinoxalin-6-ylmethyl)-5-(trifluoroacetyl)thiophene-2-carboxamide | |
0.0007 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(3-[[(4-fluorobenzyl)sulfonyl]methyl]-1,2,4-oxadiazol-5-yl)thiophen-2-yl]ethanone | |
0.00091 | - |
HDAC1, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(quinoxalin-6-yl)thiophen-2-yl]ethanone | |
0.001 | - |
IC50 above 0.001 mM, HDAC1, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(4-methoxyphenyl)thiophen-2-yl]ethanone | |
0.001 | - |
IC50 above 0.001 mM, HDAC1, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(pyridin-2-yl)thiophen-2-yl]ethanone | |
0.001 | - |
IC50 above 0.001 mM, HDAC6, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(4-methoxyphenyl)thiophen-2-yl]ethanone | |
0.001 | - |
IC50 above 0.001 mM, HDAC6, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(pyridin-2-yl)thiophen-2-yl]ethanone | |
0.0019 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(4-phenylthiophen-2-yl)ethanone | |
0.0022 | - |
HDAC1, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(5-[3-[(propylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone | |
0.0025 | - |
HDAC1, pH and temperature not specified in the publication | Homo sapiens | 4-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid | |
0.0027 | - |
HDAC1, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(5-[3-[(methylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone | |
0.0027 | - |
HDAC1, pH and temperature not specified in the publication | Homo sapiens | 4-[5-(trifluoroacetyl)thiophen-2-yl]benzonitrile | |
0.0028 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(5-phenylthiophen-2-yl)ethanone | |
0.0031 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(3-methoxyphenyl)thiophen-2-yl]ethanone | |
0.0032 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(4-phenylthiophen-2-yl)ethanone | |
0.0037 | - |
HDAC1, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(2-phenyl-1,3-thiazol-5-yl)ethanone | |
0.0038 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(3-methoxyphenyl)thiophen-2-yl]ethanone | |
0.0039 | - |
HDAC1, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(5-[3-[(thiophen-2-ylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl]thiophen-2-yl)ethanone | |
0.005 | - |
IC50 above 0.005 mM, HDAC6, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(1H-indol-5-yl)thiophen-2-yl]ethanone | |
0.0063 | - |
HDAC6, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(2-methoxyphenyl)thiophen-2-yl]ethanone | |
0.0066 | - |
HDAC1, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(3-[[(4-fluorobenzyl)sulfonyl]methyl]-1,2,4-oxadiazol-5-yl)thiophen-2-yl]ethanone | |
0.01 | - |
IC50 above 0.01 mM, HDAC1, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(4-phenylthiophen-2-yl)ethanone | |
0.01 | - |
IC50 above 0.01 mM, HDAC1, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(3-methoxyphenyl)thiophen-2-yl]ethanone | |
0.01 | - |
IC50 above 0.01 mM, HDAC1, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(2-methoxyphenyl)thiophen-2-yl]ethanone | |
0.01 | - |
IC50 above 0.01 mM, HDAC1, pH and temperature not specified in the publication | Homo sapiens | 1-[5-(4-acetylphenyl)thiophen-2-yl]-2,2,2-trifluoroethanone | |
0.01 | - |
IC50 above 0.01 mM, HDAC1, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(1H-indol-5-yl)thiophen-2-yl]ethanone | |
0.01 | - |
IC50 above 0.01 mM, HDAC1, pH and temperature not specified in the publication | Homo sapiens | 1-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)thiophen-2-yl]-2,2,2-trifluoroethanone | |
0.01 | - |
IC50 above 0.01 mM, HDAC4, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(2-methoxyphenyl)thiophen-2-yl]ethanone | |
0.01 | - |
IC50 above 0.01 mM, HDAC4, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-[5-(1H-indol-5-yl)thiophen-2-yl]ethanone | |
0.01 | - |
IC50 above 0.01 mM, HDAC4, pH and temperature not specified in the publication | Homo sapiens | 1-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)thiophen-2-yl]-2,2,2-trifluoroethanone | |
0.0128 | - |
HDAC1, pH and temperature not specified in the publication | Homo sapiens | 3-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid | |
0.02 | - |
IC50 above 0.02 mM, HDAC1, pH and temperature not specified in the publication | Homo sapiens | 2,2,2-trifluoro-1-(5-phenylthiophen-2-yl)ethanone | |
0.072 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 1-[5-(4-acetylphenyl)thiophen-2-yl]-2,2,2-trifluoroethanone | |
0.074 | - |
HDAC4, pH and temperature not specified in the publication | Homo sapiens | 4-[5-(trifluoroacetyl)thiophen-2-yl]benzoic acid |