Any feedback?
Literature summary for 3.5.1.98 extracted from
- Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin (2010), Int. J. Cancer, 127, 1332-1346.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| apicidin | - |
Homo sapiens |  |
| suberoylanilide hydroxamic acid | - |
Homo sapiens | |
| trichostatin A | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | cytoplasmic expression of HDAC1, 2 and 3 is significantly increased in carcinomas compared with benign tumors | Homo sapiens | 5737 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-2780 cell | - |
Homo sapiens | - |
| A2780/CDDP cell | - |
Homo sapiens | - |
| ES-2 cell | - |
Homo sapiens | - |
| IGROV-1 cell | - |
Homo sapiens | - |
| ovarian carcinoma cell | - |
Homo sapiens | - |
| OVCAR-3 cell | - |
Homo sapiens | - |
| SKOV-3 cell | - |
Homo sapiens | - |
| TOV-112D cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Fluor de Lys HDAC substrate + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HDAC1 | - |
Homo sapiens |
| HDAC2 | - |
Homo sapiens |
| HDAC3 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the immunohistochemical expression of nuclear HDAC1, HDAC2 and HDAC3 proteins increases stepwise in benign, borderline and malignant tumors of ovarian carcinoma. Cytoplasmic expression of HDAC1, 2 and 3 is significantly increased in carcinomas compared with benign tumors | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | suppression of HDAC3 reduces the migration and induces the expression of E-cadherin in ovarian cancer cells | Homo sapiens |
| physiological function | HDAC1 enhances cell proliferation of ovarian cancer cells, the expression of HDAC1 and HDAC2 is correlated with the proliferation marker Ki-67 expression, and HDAC3 stimulates cell migration with downregulation of E-cadherin in ovarian carcinoma | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
