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Literature summary for 3.5.1.98 extracted from

  • Halbert, J.; Ayong, L.; Equinet, L.; Le Roch, K.; Hardy, M.; Goldring, D.; Reininger, L.; Waters, N.; Chakrabarti, D.; Doerig, C.
    A Plasmodium falciparum transcriptional cyclin-dependent kinase-related kinase with a crucial role in parasite proliferation associates with histone deacetylase activity (2010), Eukaryot. Cell, 9, 952-959.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
additional information the CDK-related kinase 3-associated HDAC activities are sensitive to the class I/II HDAC inhibitor trichostatin A and to the sirtuin inhibitor nicotinamide Plasmodium falciparum
trichostatin A
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-lysine-histone H1 + H2O Plasmodium falciparum
-
 acetate + histone H1
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-lysine-histone H1 + H2O
-
 Plasmodium falciparum acetate + histone H1
-
 ?

Synonyms

Synonyms Comment Organism
HDAC
-
 Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Plasmodium falciparum