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Literature summary for 3.5.1.98 extracted from
- Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies (2009), Bioorg. Med. Chem., 17, 5219-5228.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,3-dihydrobenzoic acid | 98% residual activity at 0.5 mM | Homo sapiens |  |
| 2-hydroxybutyric acid | 96% residual activity at 0.5 mM | Homo sapiens | |
| 3,4-Dihydroxyphenyl acetic acid | 90% residual activity at 0.5 mM | Homo sapiens | |
| 3-hydroxycinnamic acid | 96% residual activity at 0.5 mM | Homo sapiens | |
| 8-hydroxyquinoline | 85% residual activity at 0.5 mM | Homo sapiens | |
| Baclofen | 98% residual activity at 0.5 mM | Homo sapiens | |
| Butyric acid | - |
Homo sapiens | |
| caffeic acid | 80% residual activity at 0.5 mM | Homo sapiens | |
| chlorogenic acid | highly potent HDAC inhibitor, 40% residual activity at 0.5 mM | Homo sapiens | |
| Cinnamic acid | 95% residual activity at 0.5 mM | Homo sapiens | |
| curcumin | highly potent HDAC inhibitor, 52% residual activity at 0.5 mM | Homo sapiens | |
| D-(-)-quinic acid | 96% residual activity at 0.5 mM | Homo sapiens | |
| dihydrocaffeic acid | 86% residual activity at 0.5 mM | Homo sapiens | |
| ferulic acid | 80% residual activity at 0.5 mM | Homo sapiens | |
| gamma-aminobutyric acid | - |
Homo sapiens | |
| indol-2-carboxylic acid | 97% residual activity at 0.5 mM | Homo sapiens | |
| isobutyric acid | 80% residual activity at 0.5 mM | Homo sapiens | |
| Mandelic acid | 85% residual activity at 0.5 mM | Homo sapiens | |
| additional information | HDAC is not inhibited by isovaleric acid, L-valine, sodium lactate, succinic acid, citric acid, benzylic acid, hippuric acid, antranilic acid (2-aminobenzoic acid), alpha-hydroxyacetonaphthone, and kojic acid | Homo sapiens | |
| phenyl butyric acid | - |
Homo sapiens | |
| phenylbutyric acid | - |
Homo sapiens | |
| propionic acid | 80% residual activity at 0.5 mM | Homo sapiens | |
| salicylic acid | 92% residual activity at 0.5 mM | Homo sapiens | |
| sodium butyrate | - |
Homo sapiens | |
| sodium phenylbutyrate | - |
Homo sapiens | |
| sorbic acid | 91% residual activity at 0.5 mM | Homo sapiens | |
| suberoyl anilide hydroxamic acid | - |
Homo sapiens | |
| tartaric acid | 90% residual activity at 0.5 mM | Homo sapiens | |
| trichostatin A | - |
Homo sapiens | |
| Valeric acid | 83% residual activity at 0.5 mM | Homo sapiens | |
| Valproic acid | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9BY41 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| tert-butyloxycarbonyl-L-Lys(acetyl)-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | tert-butyloxycarbonyl-L-Lys-7-amido-4-methylcoumarin + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HDAC8 | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00000821 | - |
Cinnamic acid | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000135 | - |
chlorogenic acid | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000504 | - |
trichostatin A | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000539 | - |
curcumin | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00247 | - |
suberoyl anilide hydroxamic acid | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0028 | - |
phenyl butyric acid | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00634 | - |
sodium phenylbutyrate | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00819 | - |
gamma-aminobutyric acid | pH and temperature not specified in the publication | Homo sapiens | |
| 0.01084 | - |
caffeic acid | pH and temperature not specified in the publication | Homo sapiens | |
| 0.136 | - |
Butyric acid | pH and temperature not specified in the publication | Homo sapiens | |
| 0.365 | - |
sodium butyrate | pH and temperature not specified in the publication | Homo sapiens | |
| 0.564 | - |
Valproic acid | pH and temperature not specified in the publication | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.115 | - |
pH and temperature not specified in the publication | Homo sapiens | curcumin | |
| 0.375 | - |
pH and temperature not specified in the publication | Homo sapiens | chlorogenic acid | |
| 2.54 | - |
pH and temperature not specified in the publication | Homo sapiens | caffeic acid | |
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