Application | Comment | Organism |
---|---|---|
medicine | because of their fundamental role in gene expression, histone deacetylase proteins are promising targets for cancer treatment | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
HDAC1 mutants are cloned into pBJ5HDAC1-F | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D99A | mutated channel residue, 25% deacetylase activity | Homo sapiens |
E98A | mutated channel residue, 120% deacetylase activity | Homo sapiens |
F150A | mutated channel residue, 12% deacetylase activity | Homo sapiens |
F205A | mutated channel residue, 20% deacetylase activity | Homo sapiens |
G149A | mutated channel residue, 10% deacetylase activity | Homo sapiens |
H141A | mutated channel residue, 20% deacetylase activity | Homo sapiens |
H28A | mutated channel residue, 20% deacetylase activity | Homo sapiens |
L271A | mutated channel residue, 12% deacetylase activity | Homo sapiens |
P29A | mutated channel residue, 18% deacetylase activity | Homo sapiens |
Y204A | mutated channel residue, 40% deacetylase activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
MS-275 | - |
Homo sapiens | |
suberoylanilide hydroxamic acid | SAHA, vorinostat | Homo sapiens | |
trichostatin A | TSA | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.066 | - |
Fluor de Lys HDAC substrate | mutant F150A | Homo sapiens | |
0.088 | - |
Fluor de Lys HDAC substrate | wild type | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | histone deacetylase proteins catalyze the removal of acetyl groups from acetylated lysines on histone substrates | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13547 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fluor de Lys HDAC substrate + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | histone deacetylase proteins catalyze the removal of acetyl groups from acetylated lysines on histone substrates | Homo sapiens | ? | - |
? | |
additional information | Fluor de Lys HDAC substrate, commercially available kit | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
histone deacetylase 1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
activity assay | Homo sapiens |