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Literature summary for 3.5.1.98 extracted from
- Acetylation of histone deacetylase 6 by p300 attenuates its deacetylase activity (2009), Biochem. Biophys. Res. Commun., 383, 88-92.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Myc-, HA- or, GFP-tagged HDAC6 are constructed in a CMV promoter-derrived mammalian expression vector, pCS4+ | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| p300 | p300 can inactivate HDAC6 by acetylation | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | HDAC6 deacetylases tubulins, best noted substrate is beta-tubulin | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | HDAC6 deacetylases tubulins, best noted substrate is beta-tubulin | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| histone deacetylase 6 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
in vitro tubulin deacetylation assay | Homo sapiens |
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Release 2023.1 (January 2023)
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