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Literature summary for 3.5.1.98 extracted from

  • Hassig, C.A.; Tong, J.K.; Fleischer, T.C.; Owa, T.; Grable, P.G.; Ayer, D.E.; Schreiber, S.L.
    A role for histone deacetylase activity in HDAC1-mediated transcriptional repression (1998), Proc. Natl. Acad. Sci. USA, 95, 3519-3524.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.98

Cloned(Commentary)

Cloned (Comment) Organism
expression in SV40 T-Ag Jurkat cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
D174N isoform HDAC1 mutant, about 5% of wild-type activity, reduced ability to bind a trapoxin-affinity matrix and decreased interaction with proteins RbAp48 and mSin3A Homo sapiens
D174N/D176N isoform HDAC1 mutant, about 3% of wild-type activity, reduced ability to bind a trapoxin-affinity matrix and decreased interaction with proteins RbAp48 and mSin3A Homo sapiens
D176N isoform HDAC1 mutant, about 3% of wild-type activity, reduced ability to bind a trapoxin-affinity matrix and decreased interaction with proteins RbAp48 and mSin3A Homo sapiens
H141A isoform HDAC1 mutant, about 20% of wild-type activity, reduced ability to bind a trapoxin-affinity matrix Homo sapiens
H141F/H199A isoform HDAC1 mutant, about 10% of wild-type activity, reduced ability to bind a trapoxin-affinity matrix and decreased interaction with proteins RbAp48 and mSin3A Homo sapiens
H199A isoform HDAC1 mutant, about 10% of wild-type activity, reduced ability to bind a trapoxin-affinity matrix and decreased interaction with proteins RbAp48 and mSin3A Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
trapoxin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens isoforms HDAC1 and HDAC2 are associated in vivo, complex is able to deacetylate all four core histones in vitro ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoforms HDAC1 and HDAC2
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoforms HDAC1 and HDAC2 are associated in vivo, complex is able to deacetylate all four core histones in vitro Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More isoforms HDAC1 and HDAC2 are associated in vivo, complex is able to deacetylate all four core histones in vitro Homo sapiens