Application | Comment | Organism |
---|---|---|
medicine | knock-down of isoform HDAC8 expression by RNAi inhibits growth of human lung, colon, and cervical cancer cell lines | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
molecular modeling of isoform HDAC8 in complex with inhibitor N-hydroxy-4-(methyl[(5-pyridin-2-yl-2-thienyl)sulfonyl]amino)benzamide | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knock-down of isoform HDAC8 expression by RNAi inhibits growth of human lung, colon, and cervical cancer cell lines | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apicidin | - |
Homo sapiens | |
N-hydroxy-4-(methyl[(5-pyridin-2-yl-2-thienyl)sulfonyl]amino)benzamide | - |
Homo sapiens | |
pyridin-3-ylmethyl (4-[[(2-aminophenyl)amino]carbonyl]benzyl)carbamate | i.e. MS27-275 | Homo sapiens | |
suberoylanilide hydroxamic acid | - |
Homo sapiens | |
trichostatin A | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | presence of two potassium ions in the structure of isoform HDAC8, one of which interacts with the key catalytic residues. Direct role of potassium in fold stabilization | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BY41 | isoforms HDAC1, HDAC3, HDAC8 | - |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000006 | - |
isoform HDAC3 | Homo sapiens | trichostatin A | |
0.0000007 | - |
isoform HDAC3 | Homo sapiens | apicidin | |
0.0000015 | - |
isoform HDAC1 | Homo sapiens | trichostatin A | |
0.000002 | - |
isoform HDAC1 | Homo sapiens | apicidin | |
0.000044 | - |
isoform HDAC3 | Homo sapiens | N-hydroxy-4-(methyl[(5-pyridin-2-yl-2-thienyl)sulfonyl]amino)benzamide | |
0.000086 | - |
isoform HDAC1 | Homo sapiens | N-hydroxy-4-(methyl[(5-pyridin-2-yl-2-thienyl)sulfonyl]amino)benzamide | |
0.000106 | - |
isoform HDAC3 | Homo sapiens | suberoylanilide hydroxamic acid | |
0.000119 | - |
isoform HDAC1 | Homo sapiens | suberoylanilide hydroxamic acid | |
0.000175 | - |
isoform HDAC8 | Homo sapiens | N-hydroxy-4-(methyl[(5-pyridin-2-yl-2-thienyl)sulfonyl]amino)benzamide | |
0.000185 | - |
isoform HDAC1 | Homo sapiens | pyridin-3-ylmethyl (4-[[(2-aminophenyl)amino]carbonyl]benzyl)carbamate | |
0.000201 | - |
isoform HDAC3 | Homo sapiens | pyridin-3-ylmethyl (4-[[(2-aminophenyl)amino]carbonyl]benzyl)carbamate | |
0.00049 | - |
isoform HDAC8 | Homo sapiens | trichostatin A | |
0.001 | - |
isoform HDAC8 | Homo sapiens | apicidin | |
0.004 | - |
isoform HDAC8 | Homo sapiens | suberoylanilide hydroxamic acid | |
0.01 | - |
isoform HDAC8 | Homo sapiens | pyridin-3-ylmethyl (4-[[(2-aminophenyl)amino]carbonyl]benzyl)carbamate |