Literature summary for 3.5.1.98 extracted from

Phiel, C.J.; Zhang, F.; Huang, E.Y.; Guenther, M.G.; Lazar, M.A.; Klein, P.S.
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen (2001), J. Biol. Chem., 276, 36734-36741.

Search for more literature for 3.5.1.98

Cloned(Commentary)

Cloned (Comment)	Organism
expression in 293T, HeLa and Neuro2A cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Valproic acid	treatment causes hyperacetylation of histones in cultured cells and activates transcription from diverse exogenous and endogenous promoters	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.4	-	isoform HDAC1, pH 8.0, 37°C	Homo sapiens	Valproic acid

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)