Literature summary for 3.5.1.98 extracted from

Fischle, W.; Dequiedt, F.; Fillion, M.; Hendzel, M.J.; Voelter, W.; Verdin, E.
Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo (2001), J. Biol. Chem., 276, 35826-35835.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	shuttling of isoform HDAC7 between cytoplasm and nucleus. Catalytic activity of HDAC7 requires interaction with isoform HDAC3 in the nucleus	Homo sapiens	5737	-
nucleus	predominant localization of isoform HDAC7, which shuttles between cytoplasm and nucleus. Catalytic activity of HDAC7 requires interaction with isoform HDAC3 in the nucleus	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8WUI4	isoform HDAC7, class II enzyme, and isoform HDAC3, class I enzyme	-

Subunits

Subunits	Comment	Organism
More	histone deacetylase activity of isoform HDAC7 maps to a C-terminal domain and is dependent on interaction with isoform HDAC3 in the nucleus. Cytoplasmic HDAC7 that is not bound to HDAC3 is inactive. Transcriptional corepressors SMRT and N-CoR may serve as critical mediators of interaction between HDAC7 and HDAC3	Homo sapiens

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Release 2023.1 (January 2023)