Literature summary for 3.5.1.98 extracted from

Harms, K.L.; Chen, X.
Histone deacetylase 2 modulates p53 transcriptional activities through regulation of p53-DNA binding activity (2007), Cancer Res., 67, 3145-3152.

Search for more literature for 3.5.1.98

Cloned(Commentary)

Cloned (Comment)	Organism
stable expression in MCF-7 cell	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	knock-down of isoform HDAC2 expression by small hairpin RNA inhibits cellular proliferation in a dose-dependent manner, which is also partly p53-dependent and induces cellular senescence. Knock-down enhances p53-dependent trans-repression and trans-activation of a subset of target genes. Enhancement is due to increased p53-DNA binding activity	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isoform HDAC2	-

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Release 2023.1 (January 2023)