Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.1.98 extracted from

  • Riester, D.; Hildmann, C.; Gruenewald, S.; Beckers, T.; Schwienhorst, A.
    Factors affecting the substrate specificity of histone deacetylases (2007), Biochem. Biophys. Res. Commun., 357, 439-445.
    View publication on PubMed
Search for more literature for 3.5.1.98

Cloned(Commentary)

Cloned (Comment) Organism
isoform HDAC8, expression in Escherichia coli. Isoforms HDAC1, HDAC6, expression in HEK-293 cell, HDAC3, expression in insect system, FLAg-tagged proteins Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00069
-
 Ac-IHK(acetyl)-7-amido-4-methylcoumarin isoform HDAC1 Homo sapiens
0.00228
-
 Ac-FEK(acetyl)-7-amido-4-methylcoumarin isoform HDAC6 Homo sapiens
0.00244
-
 Ac-DQK(acetyl)-7-amido-4-methylcoumarin isoform HDAC3 Homo sapiens
0.00303
-
 Ac-LIK(acetyl)-7-amido-4-methylcoumarin isoform HDAC1 Homo sapiens
0.00405
-
 Ac-GSK(acetyl)-7-amido-4-methylcoumarin isoform HDAC3 Homo sapiens
0.0043
-
 Ac-GGK(acetyl)-7-amido-4-methylcoumarin isoform HDAC6 Homo sapiens
0.0044
-
 Ac-KYK(acetyl)-7-amido-4-methylcoumarin isoform HDAC8 Homo sapiens
0.0046
-
 Ac-FEK(acetyl)-7-amido-4-methylcoumarin isoform HDAC3 Homo sapiens
0.005
-
 Ac-KWK(acetyl)-7-amido-4-methylcoumarin isoform HDAC1 Homo sapiens
0.0054
-
 Ac-KGK(acetyl)-7-amido-4-methylcoumarin isoform FB188 HDAH Homo sapiens
0.0056
-
 Ac-KYK(acetyl)-7-amido-4-methylcoumarin isoform HDAC1 Homo sapiens
0.00625
-
 Ac-IHK(acetyl)-7-amido-4-methylcoumarin isoform HDAC6 Homo sapiens
0.0069
-
 Ac-LYK(acetyl)-7-amido-4-methylcoumarin isoform HDAC3 Homo sapiens
0.00745
-
 Ac-KYK(acetyl)-7-amido-4-methylcoumarin isoform HDAC3 Homo sapiens
0.0091
-
 Ac-IHK(acetyl)-7-amido-4-methylcoumarin isoform HDAC8 Homo sapiens
0.01
-
 Ac-GGK(acetyl)-7-amido-4-methylcoumarin isoform HDAC3 Homo sapiens
0.01
-
 Ac-PFK(acetyl)-7-amido-4-methylcoumarin isoform HDAC8 Homo sapiens
0.0108
-
 Ac-GSK(acetyl)-7-amido-4-methylcoumarin isoform HDAC8 Homo sapiens
0.011
-
 Ac-GSK(acetyl)-7-amido-4-methylcoumarin isoform FB188 HDAH Homo sapiens
0.0117
-
 Ac-FEK(acetyl)-7-amido-4-methylcoumarin isoform HDAC1 Homo sapiens
0.0119
-
 Ac-VLK(acetyl)-7-amido-4-methylcoumarin isoform HDAC3 Homo sapiens
0.0123
-
 Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin isoform HDAC6 Homo sapiens
0.0124
-
 Ac-ILK(acetyl)-7-amido-4-methylcoumarin isoform HDAC3 Homo sapiens
0.0133
-
 Ac-GSK(acetyl)-7-amido-4-methylcoumarin isoform HDAC1 Homo sapiens
0.0138
-
 Ac-GGK(acetyl)-7-amido-4-methylcoumarin isoform HDAC1 Homo sapiens
0.0148
-
 Ac-IHK(acetyl)-7-amido-4-methylcoumarin isoform HDAC3 Homo sapiens
0.015
-
 Ac-VLK(acetyl)-7-amido-4-methylcoumarin isoform HDAC1 Homo sapiens
0.01646
-
 Ac-DQK(acetyl)-7-amido-4-methylcoumarin isoform HDAC6 Homo sapiens
0.019
-
 Ac-KSK(acetyl)-7-amido-4-methylcoumarin isoform FB188 HDAH Homo sapiens
0.0221
-
 Ac-VLK(acetyl)-7-amido-4-methylcoumarin isoform HDAC6 Homo sapiens
0.0241
-
 Ac-GSK(acetyl)-7-amido-4-methylcoumarin isoform HDAC6 Homo sapiens
0.0276
-
 Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin isoform HDAC3 Homo sapiens
0.0294
-
 Ac-LYK(acetyl)-7-amido-4-methylcoumarin isoform HDAC1 Homo sapiens
0.03
-
 Ac-LYK(acetyl)-7-amido-4-methylcoumarin isoform HDAC6 Homo sapiens
0.0353
-
 Ac-FEK(acetyl)-7-amido-4-methylcoumarin isoform FB188 HDAH Homo sapiens
0.0359
-
 Ac-FEK(acetyl)-7-amido-4-methylcoumarin isoform HDAC8 Homo sapiens
0.0391
-
 Ac-GGK(acetyl)-7-amido-4-methylcoumarin isoform HDAC8 Homo sapiens
0.046
-
 Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin isoform HDAC1 Homo sapiens
0.0489
-
 Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin isoform HDAC8 Homo sapiens
0.0666
-
 Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin isoform FB188 HDAH Homo sapiens
0.0877
-
 Ac-GGK(acetyl)-7-amido-4-methylcoumarin isoform FB188 HDAH Homo sapiens
0.107
-
 Ac-KYK(acetyl)-7-amido-4-methylcoumarin isoform FB188 HDAH Homo sapiens
0.108
-
 Ac-IHK(acetyl)-7-amido-4-methylcoumarin isoform FB188 HDAH Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-DQK(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Ac-FEK(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Ac-GGK(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Ac-GS(PO3)K(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Ac-GSK(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Ac-IHK(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Ac-ILK(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Ac-KGK(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Ac-KSK(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Ac-KWK(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Ac-KYK(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Ac-LIK(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Ac-LYK(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Ac-PFK(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
Ac-VLK(acetyl)-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?