Cloned (Comment) | Organism |
---|---|
stable expression of vanin-1 in HEK-293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
N131S | naturally occuring mutation in both African Americans and Mexican Americans, the mutation is associated with significantly lower plasma vanin-1 protein levels, the N131S vanin-1 is subjected to rapid endoplasmic reticulum-associated degradation as the underlying mechanism for its reduction, N131S vanin-1 is degraded significantly faster than wild type vanin-1 greatly reducing vanin-1 present on the plasma membrane and pantetheinase activity, overview | Homo sapiens |
T26I | naturally occuring mutation, similar vanin-1 protein levels are detected in cells expressing T26I vanin-1 compared to cells expressing wild-type vanin-1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | a glycosylphosphatidylinositol-anchored membrane pantetheinase | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O95497 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
lipoprotein | a glycosylphosphatidylinositol (GPI)-anchored membrane pantetheinase | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
pantetheinase | - |
Homo sapiens |
vanin-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | atenolol and diltiazem, two current drugs for treating hypertension, reduce the vanin-1 protein level | down |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme vanin-1 mutation N131S is associated with high blood pressure or hypertension via vanin-1 misfolding and degradation as the underlying molecular mechanism | Homo sapiens |