Literature summary for 3.5.1.92 extracted from

Jansen, P.A.; van Diepen, J.A.; Ritzen, B.; Zeeuwen, P.L.; Cacciatore, I.; Cornacchia, C.; van Vlijmen-Willems, I.M.; de Heuvel, E.; Botman, P.N.; Blaauw, R.H.; Hermkens, P.H.; Rutjes, F.P.; Schalkwijk, J.
Discovery of small molecule vanin inhibitors: new tools to study metabolism and disease (2013), ACS Chem. Biol., 8, 530-534.

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Cloned(Commentary)

Cloned (Comment)	Organism
vanin-1 is highly expressed in liver and is under transcriptional control of PPAR-alpha and nutritional statu	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
(R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-4-phenylbutyl)butanamide	i.e. RR6, design, synthesis, and characterization of a novel pantetheine analogue, RR6, that acts as a selective, reversible, and competitive vanin inhibitor at nanomolar concentration. Oral administration of RR6 in rats completely inhibits plasma vanin activity and caused alterations of plasma lipid concentrations upon fasting	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(R)-pantetheine + H2O	Rattus norvegicus	-	(R)-pantothenate + 2-aminoethanethiol	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q4KLZ0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	vanin-1 is highly expressed in liver	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(R)-pantetheine + H2O	-	Rattus norvegicus	(R)-pantothenate + 2-aminoethanethiol	-	?

Synonyms

Synonyms	Comment	Organism
vanin-1	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	vanins are enzymes with pantetheinase activity and are presumed to play a role in the recycling of pantothenic acid (vitamin B5) from pantetheine. Pantothenic acid is an essential nutrient required to synthesize coenzyme A, a cofactor involved in many biological processes such as fatty acid synthesis and oxidation of pyruvate to fuel the citric acid cycle. Hydrolysis of pantetheine also liberates cysteamine, a known antioxidant	Rattus norvegicus

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Release 2023.1 (January 2023)