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Literature summary for 3.5.1.92 extracted from

  • Zhang, B.; Lo, C.; Shen, L.; Sood, R.; Jones, C.; Cusmano-Ozog, K.; Park-Snyder, S.; Wong, W.; Jeng, M.; Cowan, T.; Engleman, E.G.; Zehnder, J.L.
    The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP (2011), Blood, 117, 4569-4579.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pantetheine + H2O Homo sapiens
-
 pantothenate + cysteamine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
granulocyte
-
 Homo sapiens
-
peripheral blood mononuclear cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pantetheine + H2O
-
 Homo sapiens pantothenate + cysteamine
-
 ?

Synonyms

Synonyms Comment Organism
vanin-1
-
 Homo sapiens
VNN1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens in lipopolysaccharide-treated cells, vanin-1 expression increases 5.1 to 40.2fold. In sodium arsenite-treated cells, vanin-1 expression increases 1.9 to 39.8fold up

General Information

General Information Comment Organism
physiological function overexpression of vanin-1 is most strongly associated with progression to chronic pediatric immune thrombocytopenia. Vanin-1 is a peripheral blood oxidative stress sensor Homo sapiens