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Literature summary for 3.5.1.92 extracted from

  • Berruyer, C.; Pouyet, L.; Millet, V.; Martin, F.M.; LeGoffic, A.; Canonici, A.; Garcia, S.; Bagnis, C.; Naquet, P.; Galland, F.
    Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity (2006), J. Exp. Med., 203, 2817-2827.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine manipulation the Vanin-1/pantetheinase activity represents an attractive therapeutic strategy for the treatment of inflammatory bowel disease Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus vanin-1, by antagonizing PPARgamma, licenses the production of inflammatory mediators by intestinal epithelial cells ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
colon epithelium. Vanin-1 controls the inflammatory response in injured colon. Vanin-1 regulates the expression of PPARgamma in epithelial cells Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information vanin-1, by antagonizing PPARgamma, licenses the production of inflammatory mediators by intestinal epithelial cells Mus musculus ?
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