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Literature summary for 3.5.1.9 extracted from

  • Seifert, J.; Casida, J.E.
    Inhibition and reactivation of chicken kynurenine formamidase: In vitro studies with organophosphates, N-alkylcarbamates, and phenylmethanesulfonyl fluoride (1979), Pestic. Biochem. Physiol., 12, 273-279.
No PubMed abstract available
Search for more literature for 3.5.1.9

Inhibitors

Inhibitors Comment Organism Structure
1-pyridine-2-aldoxime 1'-(pyridine-4-aldoxime) dimethyl ether dichloride HS-3, complete inhibition at 0.5 mM Gallus gallus
2-pyridine aldoxime 31% inhibition at 1 mM Gallus gallus
3-pyridine aldoxime O-n-propyl ether 43% inhibition at 1 mM Gallus gallus
3-pyridine aldoxime O-phenyl ether 61% inhibition at 1 mM Gallus gallus
bromphenol blue 50% inhibition at 0.024 mM after 5 min preincubation Gallus gallus
Carbaryl moderately potent teratogen, Kd: 0.085 mM Gallus gallus
diazoxon highly potent teratogen, Kd: 0.15 mM Gallus gallus
dicrotophos potent teratogen, Kd: 3.2 mM Gallus gallus
diethyl dicarbonate 90% inhibition at 0.5 mM Gallus gallus
methyl-triphenyl phosphonium bromide
-
 Gallus gallus
Monocrotophos potent teratogen, Kd: 5.4 mM Gallus gallus
N-ethyloxycarbonyl-2-ethyloxy-1,2-dihydroquinoline 53% inhibition at 1 mM Gallus gallus
NaF 42% inhibition at 5 mM Gallus gallus
NH2OH*HCl 14% inhibition at 3 mM Gallus gallus
phenyl saligenin cyclic phosphate Kd: 0.00083 mM Gallus gallus
phenylmethylsulfonyl fluoride Kd: 3.3 mM Gallus gallus
Salicyl aldoxime 71% inhibition at 1 mM Gallus gallus
tetraethyl diphosphate Kd: 67 mM Gallus gallus
tetraheptylammonium bromide 94% inhibition at 2.5 mM Gallus gallus
tetrahexylammonium bromide 56% inhibition at 5 mM Gallus gallus
tetraoctylammoniumbromide 94% inhibition at 2.5 mM Gallus gallus
tetraphenyl phosphonium bromide 22% inhibition at 5 mM Gallus gallus
trimethyl-n-decylammonium bromide 65% inhibition at 5 mM Gallus gallus
trimethyl-n-decylammonium chloride 65% inhibition at 5 mM Gallus gallus
trimethyl-n-hexadecylammonium bromide 100% inhibition at 5 mM Gallus gallus
trimethylhexadecylammonium chloride 100% inhibition at 5 mM Gallus gallus
trimethylphenylammonium bromide 20% inhibition at 5 mM Gallus gallus
trimethylphenylammonium chloride 20% inhibition at 5 mM Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.14
-
 N-formyl-L-kynurenine
-
 Gallus gallus
0.39
-
 N1,Nalpha-diformyl-L-kynurenine
-
 Gallus gallus
1
-
 2-Chloro-N-(1-naphthyl)acetamide
-
 Gallus gallus
8.1
-
 N-formyl-o-aminoacetophenone
-
 Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
 gel filtration Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-formyl-L-kynurenine + H2O Gallus gallus
-
 L-kynurenine + formate
-
 ?
N-formyl-o-aminoacetophenone + H2O Gallus gallus low activity formate + o-aminoacetophenone
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
near homogeneity, chromatography techniques Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-chloro-N-(1-naphthyl)acetamide + H2O low activity Gallus gallus chloroacetate + 1-naphthylamine
-
 ?
N-formyl-L-kynurenine + H2O
-
 Gallus gallus L-kynurenine + formate
-
 ?
N-formyl-o-aminoacetophenone + H2O low activity Gallus gallus formate + o-aminoacetophenone
-
 ?
N1,Nalpha-diformyl-L-kynurenine + H2O
-
 Gallus gallus formate + N-alpha-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
KFase
-
 Gallus gallus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
65
-
 inactivation in 35 min Gallus gallus

pH Range

pH Minimum pH Maximum Comment Organism
6.2 9.3 high activity within Gallus gallus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.024
-
 bromphenol blue after 5 min preincubation Gallus gallus