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Literature summary for 3.5.1.89 extracted from

  • Smith, T.K.; Crossman, A.; Borissow, C.N.; Paterson, M.J.; Dix, A.; Brimacombe, J.S.; Ferguson, M.A.J.
    Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors (2001), EMBO J., 20, 3322-3332.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.89

Application

Application Comment Organism
medicine comparison of substrate specificity of human and parasite enzyme Homo sapiens
medicine comparison of substrate specificity of human and parasite enzyme Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
2-deoxy-2-ureido-D-glucosyl-alpha1-6-D-myo-inositol-1-phosphoryl-sn-1,2-dipalmitoylglycerol 50% inhibition between 0.0001 and 0.001 mM Homo sapiens
2-deoxy-2-ureido-D-glucosyl-alpha1-6-D-myo-inositol-1-phosphoryl-sn-1,2-dipalmitoylglycerol 50% inhibition at 8 nM Trypanosoma brucei
2-deoxy-2-ureido-D-glucosyl-beta1-6-D-myo-inositol-1-phosphoryl-sn-1,2-dipalmitoylglycerol 50% inhibition at about 8 nM Trypanosoma brucei
2-deoxy-2-ureido-D-glucosylalpha1-6-D-(2-O-octyl)myo-inositol-1-phosphoryl-sn-1,2-dipalmitoylglycerol 50% inhibition at about 8 nM Trypanosoma brucei
additional information not inhibitory up to 0.1 mM: 2-deoxy-2-ureido-D-glucosyl-beta1-6-D-myo-inositol-1-phosphoryl-sn-1,2-dipalmitoylglycerol, 2-deoxy-2-ureido-D-glucosylalpha1-6-D-(2-O-octyl)myo-inositol-1-phosphoryl-sn-1,2-dipalmitoylglycerol Homo sapiens
N-dimethyl-D-glucosyl-phosphatidylinositol 0.001 mM, complete inhibition Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Trypanosoma brucei
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information structural requirements of substrate, enzyme can act on substrate analogues containing N-acetyl-beta-glucosyl-groups or aromatic N-acyl groups Trypanosoma brucei ?
-
 ?
additional information structural requirements of substrate, enzyme cannot act on substrate analogues containing N-acetyl-beta-glucosyl-groups or aromatic N-acyl groups Homo sapiens ?
-
 ?