Literature summary for 3.5.1.88 extracted from

Sharma, A.; Khuller, G.K.; Sharma, S.
Peptide deformylase--a promising therapeutic target for tuberculosis and antibacterial drug discovery (2009), Expert Opin. Ther. Targets, 13, 753-765.

Application

Application	Comment	Organism
medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Staphylococcus aureus
medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Bacillus subtilis
medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Escherichia coli
medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Enterobacter cloacae
medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Pseudomonas aeruginosa
medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Neisseria gonorrhoeae
medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Streptococcus pneumoniae
medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Klebsiella pneumoniae
medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Bacteroides fragilis
medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Moraxella catarrhalis
medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Staphylococcus epidermidis
medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Mycobacterium tuberculosis variant bovis
medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Stenotrophomonas maltophilia
medicine	peptide deformylase is a therapeutic target for antibacterial drug discovery	Enterococcus sp.
medicine	peptide deformylase is a therapeutic target for tuberculosis	Homo sapiens
medicine	peptide deformylase is a therapeutic target for tuberculosis	Mycobacterium tuberculosis

Inhibitors

Inhibitors	Comment	Organism
(2R)-N-[(3S)-2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4,4-dimethylpent-1-en-3-yl]-2-[[formyl(hydroxy)amino]methyl]hexanamide	-	Homo sapiens
(2R)-N-[(3S)-2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4,4-dimethylpent-1-en-3-yl]-2-[[formyl(hydroxy)amino]methyl]hexanamide	-	Mycobacterium tuberculosis
actinonin	-	Bacillus subtilis
actinonin	-	Bacteroides fragilis
actinonin	-	Enterobacter cloacae
actinonin	-	Enterococcus sp.
actinonin	-	Escherichia coli
actinonin	-	Homo sapiens
actinonin	-	Klebsiella pneumoniae
actinonin	-	Moraxella catarrhalis
actinonin	-	Mycobacterium tuberculosis
actinonin	-	Mycobacterium tuberculosis variant bovis
actinonin	-	Neisseria gonorrhoeae
actinonin	-	Plasmodium falciparum
actinonin	-	Pseudomonas aeruginosa
actinonin	-	Staphylococcus aureus
actinonin	-	Staphylococcus epidermidis
actinonin	-	Stenotrophomonas maltophilia
actinonin	-	Streptococcus pneumoniae
BB-3497	-	Bacillus subtilis
BB-3497	-	Bacteroides fragilis
BB-3497	-	Enterobacter cloacae
BB-3497	-	Enterococcus sp.
BB-3497	-	Escherichia coli
BB-3497	-	Homo sapiens
BB-3497	-	Klebsiella pneumoniae
BB-3497	-	Moraxella catarrhalis
BB-3497	-	Mycobacterium tuberculosis
BB-3497	-	Mycobacterium tuberculosis variant bovis
BB-3497	-	Neisseria gonorrhoeae
BB-3497	-	Plasmodium falciparum
BB-3497	-	Pseudomonas aeruginosa
BB-3497	-	Staphylococcus aureus
BB-3497	-	Staphylococcus epidermidis
BB-3497	-	Stenotrophomonas maltophilia
BB-3497	-	Streptococcus pneumoniae
BB-81384	-	Bacillus subtilis
BB-81384	-	Bacteroides fragilis
BB-81384	-	Enterobacter cloacae
BB-81384	-	Enterococcus sp.
BB-81384	-	Escherichia coli
BB-81384	-	Homo sapiens
BB-81384	-	Klebsiella pneumoniae
BB-81384	-	Moraxella catarrhalis
BB-81384	-	Mycobacterium tuberculosis
BB-81384	-	Mycobacterium tuberculosis variant bovis
BB-81384	-	Neisseria gonorrhoeae
BB-81384	-	Plasmodium falciparum
BB-81384	-	Pseudomonas aeruginosa
BB-81384	-	Staphylococcus aureus
BB-81384	-	Staphylococcus epidermidis
BB-81384	-	Stenotrophomonas maltophilia
BB-81384	-	Streptococcus pneumoniae
BB-83698	-	Bacillus subtilis
BB-83698	-	Bacteroides fragilis
BB-83698	-	Enterobacter cloacae
BB-83698	-	Enterococcus sp.
BB-83698	-	Escherichia coli
BB-83698	-	Homo sapiens
BB-83698	-	Klebsiella pneumoniae
BB-83698	-	Moraxella catarrhalis
BB-83698	-	Mycobacterium tuberculosis
BB-83698	-	Mycobacterium tuberculosis variant bovis
BB-83698	-	Neisseria gonorrhoeae
BB-83698	-	Plasmodium falciparum
BB-83698	-	Pseudomonas aeruginosa
BB-83698	-	Staphylococcus aureus
BB-83698	-	Staphylococcus epidermidis
BB-83698	-	Stenotrophomonas maltophilia
BB-83698	-	Streptococcus pneumoniae
tert-butyl 1-[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]hexanoyl]-L-prolinate	-	Homo sapiens
tert-butyl 1-[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]hexanoyl]-L-prolinate	-	Mycobacterium tuberculosis
VIC-104959	LBM415	Bacillus subtilis
VIC-104959	LBM415	Bacteroides fragilis
VIC-104959	LBM415	Enterobacter cloacae
VIC-104959	LBM415	Enterococcus sp.
VIC-104959	LBM415	Escherichia coli
VIC-104959	LBM415	Homo sapiens
VIC-104959	LBM415	Klebsiella pneumoniae
VIC-104959	LBM415	Moraxella catarrhalis
VIC-104959	LBM415	Mycobacterium tuberculosis
VIC-104959	LBM415	Mycobacterium tuberculosis variant bovis
VIC-104959	LBM415	Neisseria gonorrhoeae
VIC-104959	LBM415	Plasmodium falciparum
VIC-104959	LBM415	Pseudomonas aeruginosa
VIC-104959	LBM415	Staphylococcus aureus
VIC-104959	LBM415	Staphylococcus epidermidis
VIC-104959	LBM415	Stenotrophomonas maltophilia
VIC-104959	LBM415	Streptococcus pneumoniae
VRC-3375	-	Bacillus subtilis
VRC-3375	-	Bacteroides fragilis
VRC-3375	-	Enterobacter cloacae
VRC-3375	-	Enterococcus sp.
VRC-3375	-	Escherichia coli
VRC-3375	-	Homo sapiens
VRC-3375	-	Klebsiella pneumoniae
VRC-3375	-	Moraxella catarrhalis
VRC-3375	-	Mycobacterium tuberculosis
VRC-3375	-	Mycobacterium tuberculosis variant bovis
VRC-3375	-	Neisseria gonorrhoeae
VRC-3375	-	Plasmodium falciparum
VRC-3375	-	Pseudomonas aeruginosa
VRC-3375	-	Staphylococcus aureus
VRC-3375	-	Staphylococcus epidermidis
VRC-3375	-	Stenotrophomonas maltophilia
VRC-3375	-	Streptococcus pneumoniae
VRC-4307	-	Bacillus subtilis
VRC-4307	-	Bacteroides fragilis
VRC-4307	-	Enterobacter cloacae
VRC-4307	-	Enterococcus sp.
VRC-4307	-	Escherichia coli
VRC-4307	-	Homo sapiens
VRC-4307	-	Klebsiella pneumoniae
VRC-4307	-	Moraxella catarrhalis
VRC-4307	-	Mycobacterium tuberculosis
VRC-4307	-	Mycobacterium tuberculosis variant bovis
VRC-4307	-	Neisseria gonorrhoeae
VRC-4307	-	Plasmodium falciparum
VRC-4307	-	Pseudomonas aeruginosa
VRC-4307	-	Staphylococcus aureus
VRC-4307	-	Staphylococcus epidermidis
VRC-4307	-	Stenotrophomonas maltophilia
VRC-4307	-	Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
N-formyl-L-methionine-polypeptide + H2O	Staphylococcus aureus	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Bacillus subtilis	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Escherichia coli	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Homo sapiens	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Enterobacter cloacae	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Pseudomonas aeruginosa	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Neisseria gonorrhoeae	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Streptococcus pneumoniae	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Klebsiella pneumoniae	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Mycobacterium tuberculosis	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Bacteroides fragilis	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Moraxella catarrhalis	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Staphylococcus epidermidis	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Plasmodium falciparum	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Mycobacterium tuberculosis variant bovis	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Stenotrophomonas maltophilia	-	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	Enterococcus sp.	-	formate + L-methionine-polypeptide	-	?

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	-	-	-
Bacteroides fragilis	-	-	-
Enterobacter cloacae	-	-	-
Enterococcus sp.	-	-	-
Escherichia coli	-	-	-
Homo sapiens	-	-	-
Klebsiella pneumoniae	-	-	-
Moraxella catarrhalis	-	-	-
Mycobacterium tuberculosis	-	-	-
Mycobacterium tuberculosis variant bovis	-	-	-
Neisseria gonorrhoeae	-	-	-
Plasmodium falciparum	-	-	-
Pseudomonas aeruginosa	-	-	-
Staphylococcus aureus	-	-	-
Staphylococcus epidermidis	-	-	-
Stenotrophomonas maltophilia	-	-	-
Streptococcus pneumoniae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
N-formyl-L-methionine-polypeptide + H2O	-	Staphylococcus aureus	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Bacillus subtilis	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Escherichia coli	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Homo sapiens	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Enterobacter cloacae	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Pseudomonas aeruginosa	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Neisseria gonorrhoeae	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Streptococcus pneumoniae	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Klebsiella pneumoniae	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Mycobacterium tuberculosis	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Bacteroides fragilis	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Moraxella catarrhalis	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Staphylococcus epidermidis	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Plasmodium falciparum	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Mycobacterium tuberculosis variant bovis	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Stenotrophomonas maltophilia	formate + L-methionine-polypeptide	-	?
N-formyl-L-methionine-polypeptide + H2O	-	Enterococcus sp.	formate + L-methionine-polypeptide	-	?

Synonyms

Synonyms	Comment	Organism
PDF	-	Staphylococcus aureus
PDF	-	Bacillus subtilis
PDF	-	Escherichia coli
PDF	-	Homo sapiens
PDF	-	Enterobacter cloacae
PDF	-	Pseudomonas aeruginosa
PDF	-	Neisseria gonorrhoeae
PDF	-	Streptococcus pneumoniae
PDF	-	Klebsiella pneumoniae
PDF	-	Mycobacterium tuberculosis
PDF	-	Bacteroides fragilis
PDF	-	Moraxella catarrhalis
PDF	-	Staphylococcus epidermidis
PDF	-	Plasmodium falciparum
PDF	-	Mycobacterium tuberculosis variant bovis
PDF	-	Stenotrophomonas maltophilia
PDF	-	Enterococcus sp.

General Information

General Information	Comment	Organism
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Staphylococcus aureus
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Bacillus subtilis
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Escherichia coli
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Homo sapiens
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Enterobacter cloacae
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Pseudomonas aeruginosa
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Neisseria gonorrhoeae
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Streptococcus pneumoniae
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Klebsiella pneumoniae
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Mycobacterium tuberculosis
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Bacteroides fragilis
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Moraxella catarrhalis
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Staphylococcus epidermidis
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Plasmodium falciparum
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Mycobacterium tuberculosis variant bovis
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Stenotrophomonas maltophilia
physiological function	PDF plays a critical role in mediating the maturation process of the nascent polypeptides partly due to the necessity of removing the N-formyl group to render nascent polypeptides available for cleavage of the N-terminal methionine residue by methionine amino peptidase	Enterococcus sp.