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Literature summary for 3.5.1.88 extracted from

  • Berg, A.K.; Yu, Q.; Qian, S.Y.; Haldar, M.K.; Srivastava, D.K.
    Solvent-assisted slow conversion of a dithiazole derivative produces a competitive inhibitor of peptide deformylase (2010), Biochim. Biophys. Acta, 1804, 704-713.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.88

Inhibitors

Inhibitors Comment Organism Structure
2-amino-5-mercapto-1,3,4-thiadiazole slow-binding inhibitor of PDF when dissolved only in dimethylformamide, but not in any other solvent, and aged (via the formation of a disulfide bond) to a dimeric form Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.052
-
 N-formyl-L-Met-L-Leu-4-nitroanilide in 50 mM potassium phosphate buffer, pH 7.0, temperature not specified in the publication Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Ni2+ enzyme resident cofactor Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-formyl-L-methionine-polypeptide + H2O Escherichia coli
-
 formate + L-methionine-polypeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A6K3
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-formyl-L-Met-L-Leu-4-nitroanilide + H2O
-
 Escherichia coli formate + L-Met-L-Leu-4-nitroanilide
-
 ?
N-formyl-L-methionine-polypeptide + H2O
-
 Escherichia coli formate + L-methionine-polypeptide
-
 ?

Synonyms

Synonyms Comment Organism
PDF
-
 Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.17
-
 2-amino-5-mercapto-1,3,4-thiadiazole in 50 mM potassium phosphate buffer, pH 7.0, temperature not specified in the publication Escherichia coli