Cloned (Comment) | Organism |
---|---|
a truncated HsPDF lacking the first 63 amino acids, which correspond to the mitochondrial targeting sequence, is cloned into the vector pET-15b for expression in Escherichia coli BL21DE3 pLys cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
the structures of peptide deformylase and of peptide deformylase in complex with actinonin are determined at 1.7 A | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
actinonin | - |
Homo sapiens | |
BB-83698 | - |
Homo sapiens | |
LBM-415 | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.521 | - |
formyl-MLHQ | - |
Homo sapiens | |
0.738 | - |
formyl-MVHQ | - |
Homo sapiens | |
1.181 | - |
formyl-MTPM | - |
Homo sapiens | |
1.351 | - |
formyl-MFAD | - |
Homo sapiens | |
1.56 | - |
formyl-MTHQ | - |
Homo sapiens | |
2.135 | - |
formyl-MTMH | - |
Homo sapiens | |
2.287 | - |
formyl-MTHQ | - |
Homo sapiens | |
2.443 | - |
formyl-MNFA | - |
Homo sapiens | |
2.97 | - |
formyl-MRHQ | - |
Homo sapiens | |
3.01 | - |
formyl-MFHQ | - |
Homo sapiens | |
4.085 | - |
formyl-MMYA | - |
Homo sapiens | |
5.14 | - |
formyl-MGHQ | - |
Homo sapiens | |
5.76 | - |
formyl-MLKL | - |
Homo sapiens | |
8.14 | - |
formyl-MAHA | - |
Homo sapiens | |
12.44 | - |
formyl-MNPL | - |
Homo sapiens | |
24.09 | - |
formyl-MPQL | - |
Homo sapiens | |
42.9 | - |
formyl-MEHQ | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9HBH1 | - |
- |
Purification (Comment) | Organism |
---|---|
by chromatography on a Ni2+ Sepharose high-performance column, gel filtration and ammonium sulfate precipitation | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
formyl-MAHA + H2O | peptide substrate derived from mitochondrial cytochrome c oxidase subunit II | Homo sapiens | formate + MAHA | - |
? | |
formyl-MEHQ + H2O | - |
Homo sapiens | formate + MEHQ | - |
? | |
formyl-MFAD + H2O | peptide substrate derived from mitochondrial cytochrome c oxidase subunit I | Homo sapiens | formate + MFAD | - |
? | |
formyl-MFHQ + H2O | - |
Homo sapiens | formate + MMFQ | - |
? | |
formyl-MGHQ + H2O | - |
Homo sapiens | formate + MGHQ | - |
? | |
formyl-MLHQ + H2O | - |
Homo sapiens | formate + MLHQ | - |
? | |
formyl-MLKL + H2O | peptide substrate derived from mitochondrial NADH dehydrogenase subunit 4 | Homo sapiens | formate + MLKL | - |
? | |
formyl-MMYA + H2O | peptide substrate derived from mitochondrial NADH dehydrogenase subunit 6 | Homo sapiens | formate + MMYA | - |
? | |
formyl-MNFA + H2O | peptide substrate derived from mitochondrial NADH dehydrogenase subunit 3 | Homo sapiens | formate + MNFA | - |
? | |
formyl-MNPL + H2O | peptide substrate derived from mitochondrial NADH dehydrogenase subunit 2 | Homo sapiens | formate + MNPL | - |
? | |
formyl-MPQL + H2O | peptide substrate derived from mitochondrial ATP synthase F0 subunit 8 | Homo sapiens | formate + MPQL | - |
? | |
formyl-MRHQ + H2O | - |
Homo sapiens | formate + MRHQ | - |
? | |
formyl-MTHQ + H2O | - |
Homo sapiens | formate + MTHQ | - |
? | |
formyl-MTHQ + H2O | peptide substrate derived from mitochondrial cytochrome c oxidase subunit III | Homo sapiens | formate + MTHQ | - |
? | |
formyl-MTMH + H2O | peptide substrate derived from mitochondrial NADH dehydrogenase subunit 5 | Homo sapiens | formate + MTMH | - |
? | |
formyl-MTPM + H2O | peptide substrate derived from mitochondrial cytochrome b | Homo sapiens | formate + MTPM | - |
? | |
formyl-MVHQ + H2O | - |
Homo sapiens | formate + MVHQ | - |
? | |
additional information | HsPDF can process, in vitro, N-Met-formylated peptides | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
HsPDF | - |
Homo sapiens |
peptide deformylase | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00275 | - |
formyl-MLHQ | - |
Homo sapiens | |
0.0049 | - |
formyl-MLKL | - |
Homo sapiens | |
0.00581 | - |
formyl-MVHQ | - |
Homo sapiens | |
0.00937 | - |
formyl-MEHQ | - |
Homo sapiens | |
0.0134 | - |
formyl-MFHQ | - |
Homo sapiens | |
0.0155 | - |
formyl-MGHQ | - |
Homo sapiens | |
0.0174 | - |
formyl-MTPM | - |
Homo sapiens | |
0.0202 | - |
formyl-MRHQ | - |
Homo sapiens | |
0.0211 | - |
formyl-MNPL | - |
Homo sapiens | |
0.0277 | - |
formyl-MTHQ | - |
Homo sapiens | |
0.0283 | - |
formyl-MPQL | - |
Homo sapiens | |
0.0362 | - |
formyl-MTMH | - |
Homo sapiens | |
0.044 | - |
formyl-MTHQ | - |
Homo sapiens | |
0.0502 | - |
formyl-MNFA | - |
Homo sapiens | |
0.057 | - |
formyl-MFAD | - |
Homo sapiens | |
0.0646 | - |
formyl-MMYA | - |
Homo sapiens | |
0.0831 | - |
formyl-MAHA | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
activity assay | Homo sapiens |