Application | Comment | Organism |
---|---|---|
medicine | peptide deformylase is a target for the design of novel antibiotics | Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
structures of several complexes of Mycobacterium tuberculosis peptide deformylase with the inhibitors are determined at 2.0 to 1.4 A | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3R)-3-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]-N-hydroxyheptanamide | - |
Mycobacterium tuberculosis | |
(3R)-3-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]heptanoic acid | - |
Mycobacterium tuberculosis | |
(3R)-3-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]-N-hydroxyheptanamide | - |
Mycobacterium tuberculosis | |
(3R)-3-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]heptanoic acid | - |
Mycobacterium tuberculosis | |
actinonin | - |
Mycobacterium tuberculosis | |
LBK-611 | - |
Mycobacterium tuberculosis | |
N-[(2R)-2-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]heptyl]-N-hydroxyformamide | - |
Mycobacterium tuberculosis | |
N-[(2R)-2-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]hexyl]-N-hydroxyformamide | - |
Mycobacterium tuberculosis | |
N-[(2R)-2-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]pentyl]-N-hydroxyformamide | - |
Mycobacterium tuberculosis | |
N-[(2R)-2-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]heptyl]-N-hydroxyformamide | - |
Mycobacterium tuberculosis | |
N-[(2R)-2-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]hexyl]-N-hydroxyformamide | - |
Mycobacterium tuberculosis | |
N-[(2R)-2-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]pentyl]-N-hydroxyformamide | - |
Mycobacterium tuberculosis | |
N-[(2R)-3-[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide | - |
Mycobacterium tuberculosis | |
N-[(2R)-3-[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]-2-benzyl-3-oxopropyl]-N-hydroxyformamide | - |
Mycobacterium tuberculosis | |
N-[(2R)-3-[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide | - |
Mycobacterium tuberculosis | |
N-[(2R)-3-[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]-2-benzyl-3-oxopropyl]-N-hydroxyformamide | - |
Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ni2+ | - |
Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mycobacterium tuberculosis | catalyzes the removal of the N-formyl group from the N-terminus of newly synthesized proteins | ? | - |
? | |
additional information | Mycobacterium tuberculosis H37Rv | catalyzes the removal of the N-formyl group from the N-terminus of newly synthesized proteins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WIJ3 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WIJ3 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | catalyzes the removal of the N-formyl group from the N-terminus of newly synthesized proteins | Mycobacterium tuberculosis | ? | - |
? | |
additional information | catalyzes the removal of the N-formyl group from the N-terminus of newly synthesized proteins | Mycobacterium tuberculosis H37Rv | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
peptide deformylase | - |
Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000008 | - |
- |
Mycobacterium tuberculosis | N-[(2R)-3-[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide | |
0.00001 | - |
- |
Mycobacterium tuberculosis | N-[(2R)-2-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]hexyl]-N-hydroxyformamide | |
0.000013 | - |
- |
Mycobacterium tuberculosis | N-[(2R)-2-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]heptyl]-N-hydroxyformamide | |
0.000013 | - |
- |
Mycobacterium tuberculosis | N-[(2R)-2-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]hexyl]-N-hydroxyformamide | |
0.000015 | - |
- |
Mycobacterium tuberculosis | N-[(2R)-2-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]heptyl]-N-hydroxyformamide | |
0.000018 | - |
- |
Mycobacterium tuberculosis | (3R)-3-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]-N-hydroxyheptanamide | |
0.000021 | - |
- |
Mycobacterium tuberculosis | N-[(2R)-3-[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide | |
0.000024 | - |
- |
Mycobacterium tuberculosis | N-[(2R)-2-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]pentyl]-N-hydroxyformamide | |
0.000028 | - |
- |
Mycobacterium tuberculosis | N-[(2R)-2-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]pentyl]-N-hydroxyformamide | |
0.000049 | - |
- |
Mycobacterium tuberculosis | (3R)-3-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]-N-hydroxyheptanamide | |
0.000068 | - |
- |
Mycobacterium tuberculosis | N-[(2R)-3-[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]-2-benzyl-3-oxopropyl]-N-hydroxyformamide | |
0.000161 | - |
- |
Mycobacterium tuberculosis | N-[(2R)-3-[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]-2-benzyl-3-oxopropyl]-N-hydroxyformamide | |
0.000202 | - |
- |
Mycobacterium tuberculosis | (3R)-3-[[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonyl]heptanoic acid | |
0.000803 | - |
- |
Mycobacterium tuberculosis | (3R)-3-[[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl]heptanoic acid |