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Literature summary for 3.5.1.88 extracted from

  • Howard, M.H.; Cenizal, T.; Gutteridge, S.; Hanna, W.S.; Tao, Y.; Totrov, M.; Wittenbach, V.A.; Zheng, Y.J.
    A novel class of inhibitors of peptide deformylase discovered through high-throughput screening and virtual ligand screening (2004), J. Med. Chem., 47, 6669-6672.
    View publication on PubMed

Application

Application Comment Organism
medicine peptide deformylase is a promising antibacterial and herbicide target Glycine max

Inhibitors

Inhibitors Comment Organism Structure
2-thioxo-4-thiazolidinones
-
Glycine max
actinonin
-
Glycine max

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
Glycine max

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
formyl-L-methionyl peptide + H2O Glycine max
-
formate + methionyl peptide
-
?

Organism

Organism UniProt Comment Textmining
Glycine max
-
3D homology model of the matured soybean PDF2 based on the X-ray structure of the homologous enzyme from Plasmodium falciparum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formyl-L-methionyl peptide + H2O
-
Glycine max formate + methionyl peptide
-
?

Synonyms

Synonyms Comment Organism
PDF
-
Glycine max
peptide deformylase
-
Glycine max