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Literature summary for 3.5.1.88 extracted from

  • Zhou, Z.; Song, X.; Gong, W.
    Novel conformational states of peptide deformylase from pathogenic bacterium Leptospira interrogans: implications for population shift (2005), J. Biol. Chem., 280, 42391-42396.
    View publication on PubMed

Application

Application Comment Organism
medicine peptide deformylase is a target for novel antibiotics Leptospira interrogans

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop method, five LiPDF structures, resolution from 2.3-3.1 A Leptospira interrogans

Inhibitors

Inhibitors Comment Organism Structure
actinonin
-
Leptospira interrogans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
formyl-L-methionyl peptide + H2O Leptospira interrogans
-
formate + methionyl peptide
-
?

Organism

Organism UniProt Comment Textmining
Leptospira interrogans Q93LE9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formyl-L-methionyl peptide + H2O
-
Leptospira interrogans formate + methionyl peptide
-
?

Subunits

Subunits Comment Organism
dimer
-
Leptospira interrogans

Synonyms

Synonyms Comment Organism
LiPDF
-
Leptospira interrogans
PDF
-
Leptospira interrogans
peptide deformylase
-
Leptospira interrogans

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8
-
Leptospira interrogans