Literature summary for 3.5.1.88 extracted from

Fieulaine, S.; Juillan-Binard, C.; Serero, A.; Dardel, F.; Giglione, C.; Meinnel, T.; Ferrer, J.L.
The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms (2005), J. Biol. Chem., 280, 42315-42324.

Search for more literature for 3.5.1.88

Application

Application	Comment	Organism
medicine	peptide deformylase inhibitors have a strong potential to be used as antibiotics	Arabidopsis thaliana

Cloned(Commentary)

Cloned (Comment)	Organism
for over-expression in Escherichia coli	Arabidopsis thaliana

Crystallization (Commentary)

Crystallization (Comment)	Organism
using the sitting drop vapor diffusion method, two crystal forms diffract with a resolution of 2.8-2.9 A, third form yield a data set at 3.4 A resolution	Arabidopsis thaliana

Inhibitors

Inhibitors	Comment	Organism	Structure
actinonin	-	Arabidopsis thaliana

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	-	Arabidopsis thaliana

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
40000	-	gel filtration	Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
formyl-L-methionyl peptide + H2O	Arabidopsis thaliana	-	formate + methionyl peptide	-	?

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
using a Hi-Trap chelating HP nickel affinity column	Arabidopsis thaliana

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
formyl-L-methionyl peptide + H2O	-	Arabidopsis thaliana	formate + methionyl peptide	-	?

Subunits

Subunits	Comment	Organism
dimer	-	Arabidopsis thaliana

Synonyms

Synonyms	Comment	Organism
AtPDF1A	-	Arabidopsis thaliana
PDF	-	Arabidopsis thaliana
peptide deformylase	-	Arabidopsis thaliana

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)