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Literature summary for 3.5.1.60 extracted from

  • Yamano, Y.; Tsuboi, K.; Hozaki, Y.; Takahashi, K.; Jin, X.H.; Ueda, N.; Wada, A.
    Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase (2012), Bioorg. Med. Chem., 20, 3658-3665.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-(dodecyloxy)ethan-1-amine 40% remaining activity Rattus norvegicus
2-(hexadecyloxy)ethan-1-amine 91% remaining activity Rattus norvegicus
2-(tetradecyloxy)ethan-1-amine 48% remaining activity Rattus norvegicus
2-aminoethyl decanoate 89% remaining activity Rattus norvegicus
2-aminoethyl dodecanoate 74% remaining activity Rattus norvegicus
2-aminoethyl hexadecanoate 50% remaining activity Rattus norvegicus
2-aminoethyl tetradecanoate 46% remaining activity Rattus norvegicus
3-(dodecyloxy)propan-1-amine 73% remaining activity Rattus norvegicus
3-(hexadecyloxy)propan-1-amine 84% remaining activity Rattus norvegicus
3-(tetradecyloxy)propan-1-amine 71% remaining activity Rattus norvegicus
3-aminopropyl decanoate 55% remaining activity Rattus norvegicus
3-aminopropyl dodecanoate 63% remaining activity Rattus norvegicus
3-aminopropyl hexadecanoate 48% remaining activity Rattus norvegicus
3-aminopropyl tetradecanoate 46% remaining activity Rattus norvegicus
dodecyl 2-aminoacetate 34% remaining activity Rattus norvegicus
dodecyl 3-aminopropanoate 51% remaining activity Rattus norvegicus
hexadecyl 2-aminoacetate 71% remaining activity Rattus norvegicus
hexadecylamine
-
Rattus norvegicus
additional information amines with an alkyl chain of suitable length and lipophilic amines exhibit potent inhibition of the enzyme. No inhibition by N-pentadecylcyclohexanecarboxamide Rattus norvegicus
pentadecyl 2-aminoacetate 42% remaining activity Rattus norvegicus
pentadecylamine
-
Rattus norvegicus
tetradecyl 2-aminoacetate 16% remaining activity Rattus norvegicus
tetradecyl 3-aminopropanoate 30% remaining activity Rattus norvegicus
tetradecylamine
-
Rattus norvegicus
tridecyl 2-aminoacetate 11% remaining activity Rattus norvegicus
tridecyl 3-aminopropanoate 29% remaining activity Rattus norvegicus
undecylamine
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-arachidonoylethanolamine + H2O Rattus norvegicus
-
arachidic acid + ethanolamine
-
?
N-arachidonoylethanolamine + H2O Rattus norvegicus Wistar/ST
-
arachidic acid + ethanolamine
-
?
palmitoylethanolamide + H2O Rattus norvegicus
-
palmitic acid + ethanolamine
-
?
palmitoylethanolamide + H2O Rattus norvegicus Wistar/ST
-
palmitic acid + ethanolamine
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q5KTC7
-
-
Rattus norvegicus Wistar/ST Q5KTC7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-arachidonoylethanolamine + H2O
-
Rattus norvegicus arachidic acid + ethanolamine
-
?
N-arachidonoylethanolamine + H2O
-
Rattus norvegicus Wistar/ST arachidic acid + ethanolamine
-
?
palmitoylethanolamide + H2O
-
Rattus norvegicus palmitic acid + ethanolamine
-
?
palmitoylethanolamide + H2O
-
Rattus norvegicus Wistar/ST palmitic acid + ethanolamine
-
?

Synonyms

Synonyms Comment Organism
N-acylethanolamine-hydrolyzing acid amidase
-
Rattus norvegicus
NAAA
-
Rattus norvegicus
NAE-hydrolyzing acid amidase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
assay at Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0057
-
pentadecylamine pH 5.0, 37°C Rattus norvegicus
0.0118
-
tridecyl 2-aminoacetate pH 5.0, 37°C Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0057
-
pH 5.0 37°C Rattus norvegicus pentadecylamine