Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(dodecyloxy)ethan-1-amine | 40% remaining activity | Rattus norvegicus | |
2-(hexadecyloxy)ethan-1-amine | 91% remaining activity | Rattus norvegicus | |
2-(tetradecyloxy)ethan-1-amine | 48% remaining activity | Rattus norvegicus | |
2-aminoethyl decanoate | 89% remaining activity | Rattus norvegicus | |
2-aminoethyl dodecanoate | 74% remaining activity | Rattus norvegicus | |
2-aminoethyl hexadecanoate | 50% remaining activity | Rattus norvegicus | |
2-aminoethyl tetradecanoate | 46% remaining activity | Rattus norvegicus | |
3-(dodecyloxy)propan-1-amine | 73% remaining activity | Rattus norvegicus | |
3-(hexadecyloxy)propan-1-amine | 84% remaining activity | Rattus norvegicus | |
3-(tetradecyloxy)propan-1-amine | 71% remaining activity | Rattus norvegicus | |
3-aminopropyl decanoate | 55% remaining activity | Rattus norvegicus | |
3-aminopropyl dodecanoate | 63% remaining activity | Rattus norvegicus | |
3-aminopropyl hexadecanoate | 48% remaining activity | Rattus norvegicus | |
3-aminopropyl tetradecanoate | 46% remaining activity | Rattus norvegicus | |
dodecyl 2-aminoacetate | 34% remaining activity | Rattus norvegicus | |
dodecyl 3-aminopropanoate | 51% remaining activity | Rattus norvegicus | |
hexadecyl 2-aminoacetate | 71% remaining activity | Rattus norvegicus | |
hexadecylamine | - |
Rattus norvegicus | |
additional information | amines with an alkyl chain of suitable length and lipophilic amines exhibit potent inhibition of the enzyme. No inhibition by N-pentadecylcyclohexanecarboxamide | Rattus norvegicus | |
pentadecyl 2-aminoacetate | 42% remaining activity | Rattus norvegicus | |
pentadecylamine | - |
Rattus norvegicus | |
tetradecyl 2-aminoacetate | 16% remaining activity | Rattus norvegicus | |
tetradecyl 3-aminopropanoate | 30% remaining activity | Rattus norvegicus | |
tetradecylamine | - |
Rattus norvegicus | |
tridecyl 2-aminoacetate | 11% remaining activity | Rattus norvegicus | |
tridecyl 3-aminopropanoate | 29% remaining activity | Rattus norvegicus | |
undecylamine | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-arachidonoylethanolamine + H2O | Rattus norvegicus | - |
arachidic acid + ethanolamine | - |
? | |
N-arachidonoylethanolamine + H2O | Rattus norvegicus Wistar/ST | - |
arachidic acid + ethanolamine | - |
? | |
palmitoylethanolamide + H2O | Rattus norvegicus | - |
palmitic acid + ethanolamine | - |
? | |
palmitoylethanolamide + H2O | Rattus norvegicus Wistar/ST | - |
palmitic acid + ethanolamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q5KTC7 | - |
- |
Rattus norvegicus Wistar/ST | Q5KTC7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-arachidonoylethanolamine + H2O | - |
Rattus norvegicus | arachidic acid + ethanolamine | - |
? | |
N-arachidonoylethanolamine + H2O | - |
Rattus norvegicus Wistar/ST | arachidic acid + ethanolamine | - |
? | |
palmitoylethanolamide + H2O | - |
Rattus norvegicus | palmitic acid + ethanolamine | - |
? | |
palmitoylethanolamide + H2O | - |
Rattus norvegicus Wistar/ST | palmitic acid + ethanolamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
N-acylethanolamine-hydrolyzing acid amidase | - |
Rattus norvegicus |
NAAA | - |
Rattus norvegicus |
NAE-hydrolyzing acid amidase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | - |
assay at | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0057 | - |
pentadecylamine | pH 5.0, 37°C | Rattus norvegicus | |
0.0118 | - |
tridecyl 2-aminoacetate | pH 5.0, 37°C | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0057 | - |
pH 5.0 37°C | Rattus norvegicus | pentadecylamine |