Cloned (Comment) | Organism |
---|---|
gene UPB1, DNA and amino acid sequence determination and analysis, genotyping, reverse transcription and quantitative real-time PCR enzyme expression analysis, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UBR1 | gene UPB1 | - |
Synonyms | Comment | Organism |
---|---|---|
BUP1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme mutational analysis: association between the c.-80C>G (rs2070474) genetic enzyme variant and gastrointestinal toxicity, strong positive correlation between the carriers of the c.-80GG genotype and the development of severe (grade 3-4) mucositis. Gene UPB1 variants may contribute to the development of 5-fluorouracil-related toxicity in some fluoropyrimidine-treated patients, but with less importance that the alterations in the dihydropyrimidine dehydrogenase (EC 1.3.1.2) gene | Homo sapiens |
metabolism | the beta-ureidopropionase enzyme catalyzes the final step in the 5-fluorouracil catabolic pathway | Homo sapiens |