Literature summary for 3.5.1.52 extracted from

Kim, I.; Ahn, J.; Liu, C.; Tanabe, K.; Apocadaca, J.; Suzuki, T.; Rao, H.
The Png1-Rad23 complex regulates glycoprotein turnover (2006), J. Cell Biol., 172, 211-219.

Search for more literature for 3.5.1.52

Cloned(Commentary)

Cloned (Comment)	Organism
expression of His- or FLAG-tagged wild-type and mutant enzymes, co-expression with Rad23	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
H218Y	site-directed mutagenesis, the mutant is inactive in protein glycosylation, but interacts with protein Rad23	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Saccharomyces cerevisiae	5829	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Saccharomyces cerevisiae	the cytosolic enzyme deglycosylates misfolded glycoproteins prior to the endoplasmic reticulum-associated protein degradation	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	several strains, overview	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the cytosolic enzyme deglycosylates misfolded glycoproteins prior to the endoplasmic reticulum-associated protein degradation	Saccharomyces cerevisiae	?	-	?
ricin A + H2O	deglycosylation of ricin A, the enzyme acts in complex with protein Rad23, interaction and complex formation analysis, overview	Saccharomyces cerevisiae	?	-	?

Subunits

Subunits	Comment	Organism
More	enzyme-Rad23 interaction and complex formation analysis, the UBA domain of Rad23 is required, rad mutant does not interact with the enzyme, overview	Saccharomyces cerevisiae

Synonyms

Synonyms	Comment	Organism
PNG1	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)