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Literature summary for 3.5.1.52 extracted from

  • Blom, D.; Hirsch, C.; Stern, P.; Tortorella, D.; Ploegh, H.L.
    A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised (2004), EMBO J., 23, 650-658.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.52

Protein Variants

Protein Variants Comment Organism
additional information construction of PNGase U-373MG siRNA cell lines, the glycosylated type I membrane protein class I MHC HC, dislocated by US2 protein, becomes cytosolic when peptide: N-glycanase is compromised, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
class I MHC HC + H2O Homo sapiens the enzyme is involved proteasomal degradation of glycosylated type I membrane protein class I MHC heavy chain, dislocated from ER to cytosol by cytomegalovirus-encoded glycoprotein US2 protein, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U-373MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
class I MHC HC + H2O the enzyme is involved proteasomal degradation of glycosylated type I membrane protein class I MHC heavy chain, dislocated from ER to cytosol by cytomegalovirus-encoded glycoprotein US2 protein, overview Homo sapiens ?
-
 ?
class I MHC HC + H2O the enzyme deglycosylates dislocated membrane protein class I MHC heavy chain Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
peptide: N-glycanase
-
 Homo sapiens
PNG1
-
 Homo sapiens
PNGase
-
 Homo sapiens