Literature summary for 3.5.1.5 extracted from

Ndemangou, B.; Sielinou, V.T.; Vardamides, J.C.; Ali, M.S.; Lateef, M.; Iqbal, L.; Afza, N.; Nkengfack, A.E.
Urease inhibitory isoflavonoids from different parts of Calopogonium mucunoides (Fabaceae) (2013), J. Enzyme Inhib. Med. Chem., 28, 1156-1161.

Search for more literature for 3.5.1.5

Inhibitors

Inhibitors	Comment	Organism	Structure
2',4',5',7-tetramethoxyisoflavone	-	Helicobacter pylori
4'-O-methylalpinumisoflavone	-	Helicobacter pylori
4'-O-methylderrone	-	Helicobacter pylori
6a,12a-dehydroxydegueline	-	Helicobacter pylori
7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one	-	Helicobacter pylori
7-O-methylcuneantin	-	Helicobacter pylori
alpinumisoflavone	-	Helicobacter pylori
atalantoflavone	-	Helicobacter pylori
Calopogonium isoflavone A	-	Helicobacter pylori
additional information	enzyme inhibition by flavonoids from tropicaal herb Calopogonium mucunoides,overview. No or poor inhibition by cabreuvin and 7-O-methylpseudobaptigenin	Helicobacter pylori
Thiourea	-	Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
urea + H2O	Helicobacter pylori	-	CO2 + 2 NH3	-	?

Organism

Organism	UniProt	Comment	Textmining
Helicobacter pylori	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
urea + H2O	-	Helicobacter pylori	CO2 + 2 NH3	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Helicobacter pylori

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8.2	-	assay at	Helicobacter pylori

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0079	-	pH 8.2, 30°C	Helicobacter pylori	7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
0.0084	-	pH 8.2, 30°C	Helicobacter pylori	7-O-methylcuneantin
0.0111	-	pH 8.2, 30°C	Helicobacter pylori	6a,12a-dehydroxydegueline
0.012	-	pH 8.2, 30°C	Helicobacter pylori	4'-O-methylderrone
0.0126	-	pH 8.2, 30°C	Helicobacter pylori	2',4',5',7-tetramethoxyisoflavone
0.0173	-	pH 8.2, 30°C	Helicobacter pylori	atalantoflavone
0.0216	-	pH 8.2, 30°C	Helicobacter pylori	Thiourea
0.0254	-	pH 8.2, 30°C	Helicobacter pylori	4'-O-methylalpinumisoflavone
0.0944	-	pH 8.2, 30°C	Helicobacter pylori	Calopogonium isoflavone A
0.232	-	pH 8.2, 30°C	Helicobacter pylori	alpinumisoflavone

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Release 2023.1 (January 2023)